| CAS: | 978-62-1 | ||
| 分子式: | C15H8ClF6NO2 | ||
| 分子量: | 383.67 | ||
| 英文名称: |
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| 用途: | IMD 0354是一种IKKβ抑制剂，作用于NF-κβ通路，抑制IκBα磷酸化。在HMC-1细胞中IMD-0354 (< 5 μM)抑制NF-κB的表达以及它的移动入核。IMD-0354抑制HMC-1细胞增殖，具有时间和剂量依赖特性。 IMD-0354 (0.5 μM)几乎可以抑制IC-2G559和IC-2V814的细胞增殖。IMD-0354 (0.5 μM)导致HMC-1细胞周期停滞在G0/G1期。IMD-0354 (1 μM)增加带有亚二倍DNA的HMC-1细胞数。在HMC-1细胞中IMD-0354 (<1 μM)降低了S期与G2/M期细胞数的比值，IMD-0354 (1 μM) 降低Cyclin D3表达和pRb磷酸化并且具有时间依赖特性。在HMC-1细胞中IMD-0354 (< 10 μM)对STAT3 和 STAT6的信号没有影响，而在高浓度时会轻微抑制STAT1 和 STAT5的磷酸化。 CBhCMCs中IMD-0354处理24小时后抑制NF-κB转移入核并且具有剂量依赖特性[1]。在HepG2细胞中10 μg/mL的IMD-0354可以抑制NF-κB 98.5%的活性[2]。血清饥饿处理12小时后3T3-L1脂肪细胞中同时使用TNFα (6 nM) 和胰岛素(100 nM)时，IMD-0354 (1 μM)可以促进TNFα诱导的脂联素浓度的下降，还可以使TNFα处理后下降的Akt磷酸化水平恢复[3]。在培养的心肌细胞中IMD-0354 (1 μM)抑制IκBα磷酸化以及TNF-α诱导的NF-κB核转位，明显抑制TNF-α诱导的白细胞介素-1β和单核细胞趋化蛋白-1的产生[4]。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||
| I872357 | MACKLIN | IMD 0354 | 99% | 39元/1mg; 129元/5mg; 299元/25mg; 788元/100mg; | 展开 | ||||||||||||||||||||||||||||||||||||
储存：-20℃ 状态：白色到灰白色固体 | |||||||||||||||||||||||||||||||||||||||||
| I792283 | MACKLIN | IMD 0354 | 10mM in DMSO | 538元/1ml; | 展开 | ||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||
| 978460 | J&K | IMD-0354 | 99%, 一种合成的选择性NF-kB 抑制剂 | 2456元/5MG; 9971元/25MG; | 展开 | ||||||||||||||||||||||||||||||||||||
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| 401482 | Sigma-Aldrich | IKK-2 Inhibitor V-CAS 978-62-1-Calbiochem | The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. | 3806.77元/5 MG; | 展开 | ||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC50 ~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50<1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKAy mice by regulating adiponectin release. 包装 5 mg in Plastic ampoule 生化/生理作用 Cell permeable: yes 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun.323, 242. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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| I3159 | Sigma-Aldrich | IMD-0354 | ≥98% (HPLC), solid | 2717.89元/5 MG; 5007.85元/10 MG; | 展开 | ||||||||||||||||||||||||||||||||||||
产品说明 应用 IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts. 包装 5, 10 mg in glass bottle 生化/生理作用 IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. [4] 基本信息
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