CAS 97657-92-6; dimebon dihydrochloride hydrate

CAS:

97657-92-6

分子式:

C₂₁H₂₅N₃·₂HCl

分子量:

392.37

英文名称:

dimebon dihydrochloride hydrate

2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole dihydrochloride hydrate

dimebone dihydrochloride hydrate

dimeboline dihydrochloride hydrate

dimebolin dihydrochloride hydrate

用途:

Latrepirdine具有口服活性及神经活性，可以作为包括histamine receptors, GluR, 和5-HT receptors在内的多个药物靶点的拮抗剂，用作抗组织胺的药物。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

L872605

MACKLIN

Latrepirdine 2HCl

99%

469元/5mg; 749元/10mg; 1519元/25mg; 4158元/100mg;

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储存：-20℃
状态：白色到灰白色粉末

D6196

Sigma-Aldrich

Dimebon dihydrochloride hydrate

≥98% (HPLC)

1376.29元/5 MG; 5482.04元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

特点和优势

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₂₁H₂₅N₃ · 2HCl · xH₂O
分子量	392.37 (anhydrous basis)
MDL编号	MFCD17215933
PubChem化学物质编号	329798824
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to off-white
溶解性	H₂O: ≥10 mg/mL
创始人	Pfizer
储存温度	2-8℃
SMILES string	O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4
InChI	1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2
InChI key	QQHQMWVYYVVAOV-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319
预防措施声明	P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable