CAS 97534-21-9; hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid

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货号

品牌

产品名称

规格

包装、参考价格

M938227

MACKLIN

NSC 336628

≥99%

907元/5mg;

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储存：2-8°C，密封，干燥
状态：固体

M2070

Sigma-Aldrich

Merbarone

≥98% (HPLC), solid

1515.08元/25 MG;

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产品说明

应用

Merbarone has been used to study its effect on the occurrence of DNA lesions.

包装

25 mg in glass bottle

生化/生理作用

Thiobarbituric acid with aniline joined by an amide linkage forms merbarone. It is known to prolong cell cycle progression by inducing DNA double strand breaks, retarding S phase and arresting G2 phase. This delays cell entry into mitosis. Merbarone possesses cytotoxic and genotoxic action and promotes endoreduplication. Merbarone has mild antitumor action and is also found to nephrotoxic.
Selective topoisomerase II inhibitor. Blocks topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. Induces apoptosis in CEM cells via caspase 3 dependent mechanism.

基本信息

经验(实验)分子式	C₁₁H₉N₃O₃S
分子量	263.27
MDL编号	MFCD00866337
PubChem化学物质编号	24724534

产品性质

测定	≥98% (HPLC)
形式	solid
drug control	regulated under CDSA - not available from sigma-aldrich Canada
溶解性	DMSO: >5 mg/mL
储存温度	2-8℃
SMILES string	O=C1NC(=S)NC(=O)C1C(=O)Nc2ccccc2
InChI	1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
InChI key	JARCFMKMOFFIGZ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

445800

Sigma-Aldrich

Merbarone-CAS 97534-21-9-Calbiochem

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes.

1903.37元/25 MG;

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产品说明

一般描述

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC₅₀ = 20 µM for purified mammalian topo II versus IC₅₀ = ~ 200 µM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.
A cell-permeable, anticancer drug that inhibits the catalytic activity of DNA topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC₅₀ = 20 µM for purified mammalian topoisomerase II versus IC₅₀ ~200 µM for topoisomerase I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Catalytic activity of topoisomerase II
Target IC₅₀: 20 µM for purified topoisomerase II (topo II)

警告

Toxicity: Standard Handling (A)

其他说明

Khelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
Drake, F.H., et al. 1989. Cancer Res.49, 2578.
Brewer, A.D., et al. 1985. Biochem. Pharmacol.34, 2047.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₁H₉N₃O₃S
分子量	263.27
MDL编号	MFCD00866337

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	faint pink
溶解性	DMSO: 100 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18)
InChI key	GFYRZTLCYQQVHZ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable