| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| C793186 | MACKLIN | CPI-613 | 10mM in DMSO | 644元/1ml; | 展开 |
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| C861064 | MACKLIN | CPI-613 | >98% | 188元/5mg; 288元/10mg; 488元/25mg; 905元/100mg; | 展开 |
储存：-20℃ 状态：白色固体 折射率：white solid |
| B5368 | TCI | 6,8-Bis(benzylthio)octanoic Acid | >98.0%(T)(HPLC) | 195元/5MG; 850元/25MG; | 展开 |
基本信息 | 纯度/分析方法 | >98.0%(T)(HPLC) | | 分子式/分子量 | C22H28O2S2 = 388.58 | | 外观与形状(20℃) | 固体 | | Reaxys-RN | 3424180 | | PubChem物质ID | 354335244 | | MDL编号 | MFCD22420826 |
技术规格 | Appearance | White to Light yellow powder to crystal | | Purity(HPLC) | min. 98.0 area% | | Purity(Neutralization titration) | min. 98.0 % |
物性(参考值) 安全信息 | 图形或危害标志 |  | | 信号词 | 警告 | | 危险性说明 | H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
| | 防范说明 | P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
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| SML0404 | Sigma-Aldrich | 6,8-Bis(benzylthio)-octanoic acid | ≥98% (HPLC) | 1254.85元/5 MG; 5072.62元/25 MG; | 展开 |
产品说明 应用 6,8-Bis(benzylthio)-octanoic acid has been used as pyruvate dehydrogenase (PDH) inhibitor:
- to study its effects on neurite outgrowth in primary mouse dorsal root ganglia cells
- to induce α-smooth muscle actin (αSMA) and pro-collagen I expression and to assess PDH enzyme activity in whole-cell lysates
- to validate basal respiration in tissue respirometry
包装 5, 25 mg in glass bottle 生化/生理作用 6,8-Bis(benzylthio)-octanoic acid (CPI-613) is a lipoate analog. It acts as a mitochondrial disrupter by blocking the mitochondrial enzymes pyruvate dehydrogenase and α-ketoglutarate dehydrogenase.
6,8-Bis(benzylthio)-octanoic acid is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. 6,8-Bis(benzylthio)-octanoic acid has been granted orphan drug status by the US FDA for pancreatic cancer. 其他说明 Air Sensitive 基本信息 | 经验(实验)分子式 | C22H28O2S2 | | 分子量 | 388.59 | | MDL编号 | MFCD22420826 | | PubChem化学物质编号 | 329825400 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | powder | | 颜色 | white to beige | | 溶解性 | DMSO: 15 mg/mL (clear solution) | | 储存温度 | 2-8℃ | | SMILES string | OC(=O)CCCCC(CCSCc1ccccc1)SCc2ccccc2 | | InChI | 1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24) | | InChI key | ZYRLHJIMTROTBO-UHFFFAOYSA-N |
安全信息 | 象形图 |  | | 警示用语： | Warning | | 危险声明 | H410 | | 预防措施声明 | P273 - P501 | | 危险分类 | Aquatic Acute 1 - Aquatic Chronic 1 | | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 468367 | Fluorochem | CPI-613 | 95% | 4642元/50mg; 13860元/250mg; 40216元/1g; | 展开 |
基本信息 | CAS Number | 95809-78-2 | | MDL Number | MFCD22420826 |
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