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CAS: 957-68-6
分子式: C10H12N2O5S
分子量: 272.28
熔点: 300℃
中文名称: 
7-氨基头孢霉烷酸
7-ACA
7-氨基头孢菌酸
7-氨基头孢烷酸
7-氨基-3-[(乙酰氧)甲基]-8-氧代-5-硫杂-1-氮杂二环[4,2,0]-2-烯-2-羧酸
7-氨基磷酸
英文名称: 
7-aminocephalosporanic acid
性质描述: 结晶体。
生产方法: 从半合成头孢菌素的基本原料——头孢菌素C出发，用三甲基氯硅烷酯化，再经五氯化磷氯化、丁醇醚化，最后水解而得。从头孢菌素C钠到7-ACA的收率约50%。
用途: 医药中间体。是许多半合成头孢菌素的起始原料。各种半合成头孢菌素的工业生产，是由发酵制得头孢菌素C。再用化学裂解获得母核7-ACA，然后进行化学改造的途径制取的。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
A798029MACKLIN7-氨基头孢烷酸2mM in DMSO186元/1ml;   展开
储存：-20°C
A800132MACKLIN7-氨基头孢烷酸97%28元/1g;   33元/5g;   64元/25g;   237元/100g;   1135元/500g;   展开
储存：2~8°C
状态：白色到浅黄色到浅橙色粉末到晶体
A1266TCI7-Aminocephalosporanic Acid>97.0%(T)(HPLC)190元/5G;   690元/25G;   展开

基本信息

纯度/分析方法>97.0%(T)(HPLC)
分子式/分子量C10H12N2O5S = 272.28
外观与形状(20℃)固体
PubChem物质ID87562732
Merck Index (14)434
MDL编号MFCD00005177

技术规格

AppearanceWhite to Light yellow to Light orange powder to crystal
Purity(HPLC)min. 97.0 area%
Purity(Neutralization titration)min. 97.0 %
Specific rotation [a]20/D+88.0 to +92.0 deg(C=0.5, buffer sol.pH7.0 KH2PO4)

物性(参考值)

比旋光度 [α]D90° (C=0.5,buffer sol. pH7.0 KH2PO4)

安全信息

图形或危害标志
信号词危险
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H317 : 可能造成皮肤过敏反应。
H334 : 吸入可能导致过敏或哮喘病症状或呼吸困难。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P261 : 避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾。
P272 : 受沾染的工作服不得带出工作场地。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P284 : [在通风不足的情况下]戴呼吸防护装置。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P342 + P311 : 如有呼吸系统病症：呼叫急救中心/医生。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P304 + P340 : 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P333 + P313 : 如发生皮肤刺激或皮疹：求医/就诊。
271995J&K7-Aminocephalosporanic Acid97%, 一种有效的β-内酰胺酶抑制剂66元/1G;   135元/5G;   538元/25G;   展开

基本信息

分子式C10H12N2O5S
分子量272.27
熔点300
比旋光度([α]20D) +88° to +100° (C=0.5, KH2PO4/NaOH)
MDL编码MFCD00005177
Beilstein622637
EINECS 编号213-485-0
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H317
H334
防范说明P261
P280
P342+P311
WGK3
191140Sigma-Aldrich7-Aminocephalosporanic Acid98%383.97元/5 G;   展开

产品说明

一般描述

化学结构:β-内酰胺

应用

细菌(金黄色葡萄球菌)β-内酰胺酶的有效抑制剂。
7-Aminocephalosporanic acid (7-ACA) can be used as a starting material to synthesize:

  • Cefotaxime by acylation reaction with S-benzothiazol-2-yl(2-amino-4-thiazolyl)(methoxyimino)thioacetate (MAEM) in the presence of triethylamine.
  • Cefpodoxime proxetil, a third-generation antibiotic via cefotaxime intermediate.
  • Sodium 3′-substituted cephalosporanate sulfone derivatives as potential inhibitors of β-lactamase.

包装

5 g in glass bottle

基本信息

经验(实验)分子式C10H12N2O5S
分子量272.28
Beilstein622637
EC 号213-485-0
MDL编号MFCD00005177
PubChem化学物质编号24851470
NACRESNA.22

产品性质

质量水平200
测定98%
形式powder
旋光性[α]19/D +90°, c = 0.5 in KH2PO4/trace NaOH
reaction suitabilityreaction type: solution phase peptide synthesis
mp>300 ℃ (lit.)
抗生素抗菌谱Gram-positive bacteria
application(s)peptide synthesis
作用机制cell wall synthesis | interferes
储存温度2-8℃
SMILES string[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2N)C(O)=O
InChI1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1
InChI keyHSHGZXNAXBPPDL-HZGVNTEJSA-N

安全信息

象形图GHS08
警示用语：Danger
危险声明H317 - H334
预防措施声明P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
危险分类Resp. Sens. 1 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
PHR2436SupelcoCefazolin Impurity HPharmaceutical Secondary Standard; Certified Reference Material6146.58元/100 MG;   展开

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC4534 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C10H12N2O5S
分子量272.28
Beilstein622637
MDL编号MFCD00005177

产品性质

等级certified reference material
pharmaceutical secondary standard
形式powder
包装pkg of 100 mg
mp>300 ℃ (lit.)
储存温度-10 to -25℃
SMILES string[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2N)C(O)=O
InChI1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1
InChI keyHSHGZXNAXBPPDL-HZGVNTEJSA-N

安全信息

象形图GHS08
警示用语：Danger
危险声明H317 - H334
预防措施声明P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
危险分类Resp. Sens. 1 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
221586Fluorochem7-Aminocephalosporanic Acid95%220元/1g;   594元/10g;   1188元/25g;   2970元/100g;   展开

基本信息

CAS Number957-68-6
MDL NumberMFCD00005177
Density1.6

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear .
P285: In case of inadequate ventilation wear respiratory protection.
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P304 + P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342 + P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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