| CAS: | 955091-53-9 | ||||
| 分子式: | C58H79N15O16 | ||||
| 分子量: | 1242.37 | ||||
| 中文名称: |
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| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||
| P984328 | MACKLIN | 10Panx | 2219元/5mg; | 展开 | |||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||
| SML2152 | Sigma-Aldrich | 10Panx1 trifluoroacetate salt | ≥98% (HPLC) | 2386.28元/1 MG; | 展开 | ||||||||||||||||||||||||||
产品说明 应用 10Panx1 trifluoroacetate salt has been used as the selective pannexin-1 mimetic inhibitory peptide to study the involvement of pannexin-1 in praliciguat (PRL) inhibition of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome. 生化/生理作用 The pannexin-1 (panx1) extracellular sequence-derived 10panx1 functions as a reversible panx1 channel blocker (IC50 = 52 μM; human panx1-overexpressing HEK cells) that effectively inhibits ATP-induced dye-uptake in panx1 HEK cells co-expressing rat or human P2X7R (IC50 = 93 μM), as well as in murine J774 and human alveolar macrophages (Effective conc. 100-200 μM). 10panx1 (100 μM) is shown to protect rat hippocampal neurons against death induction upon NMDAR overactivation by excitotoxic concentrations of NMDA (100 μM) in cultures and ameliorate withdrawal symptoms among morphine-treated rats in vivo (10 μg/rat via intrathecal injection). 基本信息
产品性质
安全信息
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