CAS 94944-70-4; 2-acetyl-4(5)-tetrahydroxybutylimidazole

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产品名称

规格

包装、参考价格

详情

A913194

MACKLIN

2-Acetyl-5-tetrahydroxybutyl Imidazole

98%

1686元/1mg; 3310元/5mg;

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储存：-20°C，密闭，干燥
状态：白色到灰白色到浅黄色到黄色到浅棕色粉末

H63416

Alfa Aesar

2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole

97%

0元/250mg;

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应用
2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole used for treatment of autoimmune disorders.

备注
Refrigerate. Keep container tightly closed. Store away from oxidizing agent.

基本信息

MDL
MFCD08752516

分子式
C₉H₁₄N₂O₅

分子量
230.22

灵敏度
Keep Cold.

形态
Powder

溶解性
Soluble in distilled water, DMSO (>5 mg/ml), clear (warmed), and PBS pH 7.2 (～0.15 mg/ml).

GHS危害和防范说明

GHS符号

Hazard Statements
H302
Harmful if swallowed.

Precautionary Statements
P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Do not eat, drink or smoke when using this product.Rinse mouth.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22
Harmful if swallowed.

安全等级
36-60
Wear suitable protective clothing.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

TSCA
否

T6330

Sigma-Aldrich

THI

2474.25元/1 MG; 8049.58元/5 MG; 20956.7元/25 MG;

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产品说明

包装

1, 5, 25 mg in glass bottle

生化/生理作用

已知 2-乙酰基-4-四羟基丁基咪唑 (THI) 可诱导大鼠外周血淋巴细胞减少。大鼠研究也有报道 THI 可影响淋巴细胞迁移和降解。
THI 是鞘氨醇-1-磷酸裂解酶的抑制剂，起到免疫抑制剂的作用。鞘氨醇-1-磷酸 (S1P) 裂解酶催化 S1P 不可逆地分解为十六醛和磷酸乙醇胺。减少 S1P 裂解酶活性导致免疫抑制的治疗水平，而没有合成的 S1P 受体激动剂导致的非淋巴病变。

制备说明

THI 可溶于 DMSO，浓度大于 5 mg/mL。

基本信息

经验(实验)分子式	C₉H₁₄N₂O₅
分子量	230.22
MDL编号	MFCD08752516
PubChem化学物质编号	329826636
NACRES	NA.77

产品性质

形式	powder
质量水平	100
颜色	white to light brown
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
InChI	1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
InChI key	CQSIXFHVGKMLGQ-BWZBUEFSSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

857393P

Avanti

THI

2-acetyl-5-tetrahydroxybutyl imidazole, powder

2215.34元/1 MG;

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产品说明

一般描述

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.
2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate lyase (S1P lyase).

生化/生理作用

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyase in vivo and up-regulates circulatory and tissue S1P levels. It has the ability to repress dystrophic muscle degeneration.

包装

5 mL Amber Glass Screw Cap Vial (857393P-1mg)

基本信息

经验(实验)分子式	C₉H₁₄N₂O₅
分子量	230.22
NACRES	NA.25

产品性质

测定	>98% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (857393P-1mg)
manufacturer/tradename	Avanti Polar Lipids 857393P
运输	dry ice
储存温度	−20℃
InChI	1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
InChI key	CQSIXFHVGKMLGQ-BWZBUEFSSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable