CAS 94470-67-4; cromakalim

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CAS:

94470-67-4

分子式:

C₁₆H₁₈N₂O₃

分子量:

286.3

英文名称:

cromakalim

用途:

(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 μM) and cardioprotective (IC50 = 0.03 μM) effects in rat hearts.

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

C913171

MACKLIN

(±)-Cromakalim

98%

1166元/10mg;

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储存：-20°C，密闭，干燥

C1055

Sigma-Aldrich

Cromakalim

2490.59元/10 MG; 8882.29元/50 MG;

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产品说明

应用

Cromakalim has been used:

as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.

包装

10, 50 mg in glass bottle

生化/生理作用

Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₆H₁₈N₂O₃
分子量	286.33
MDL编号	MFCD00133201
PubChem化学物质编号	24891962
NACRES	NA.77

产品性质

质量水平	200
储存温度	2-8℃
SMILES string	CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N
InChI	1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
InChI key	TVZCRIROJQEVOT-CABCVRRESA-N
Gene Information	rat ... Kcna1(24520), Kcnj1(24521), Kcnj5(29713), Kcnj8(25472)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

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