| CAS: | 942487-16-3 | ||
| 分子式: | C23H25F3N6O2 | ||
| 分子量: | 474.48 | ||
| 英文名称: |
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| 用途: | PF-03814735是一种新型有效的，可逆Aurora A/B抑制剂，IC50为0.8 nM/5 nM，对Flt3， FAK， TrkA作用效果稍弱，对Met和FGFR1具有最低限度的作用活性。Phase 1。在完整细胞中，PF-03814735对Aurora1和Aurora2激酶的抑制活性降低磷酸-Aurora1 (Thr 232，Aurora1活性的敏感指标，IC50 ~ 20 nM)，磷酸化组蛋白H3 (IC50 ~ 50 nM)，和磷酸-Aurora2 (IC50 ~150 nM)的水平。PF-03814735阻断细胞质分裂，从而抑制细胞增殖和多倍体多核细胞的形成。[1]一项最近的研究表明小细胞肺癌(SCLC)和，在较小程度上，结肠癌细胞系均对PF-03814735非常敏感。Myc基因家族和成视网膜细胞瘤通路成员的状态与PF-03814735的功效显著相关。[1] |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||
| P873219 | MACKLIN | PF-03814735 | 99% | 560元/1mg; | 咨询 | ||||||||||||||||||||||||||||||||
储存：-20℃ 状态：粉末 | |||||||||||||||||||||||||||||||||||||
| PZ0218 | Sigma-Aldrich | PF-03814735 | ≥98% (HPLC) | 1117.23元/5 MG; 4464.28元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||
产品说明 生化/生理作用 PF-03814735 is a potent inhibitor of Aurora kinase A and B (IC50 = 5 and 0.8 nM, respectively). PF-03814735 inhibits proliferation of tumor cells in culture and in xenograft tumor models. The compound PF-03814735 blocks phosphorylation of Aurora B and Histone H3, and leads to the formation of polyploid cells in culture (HCT116 and MDA-MB-231). 其他说明 This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer. 法律信息 Sold for research purposes under agreement from Pfizer Inc. 基本信息
产品性质
安全信息
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