CAS 93957-55-2; 氟伐他汀钠; 3,5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-6-heptenoic aci

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货号

品牌

产品名称

规格

包装、参考价格

F793763

MACKLIN

氟伐他汀钠水合物

10mM in DMSO

521元/1ml;

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储存：-20°C

F863486

MACKLIN

Fluvastatin Sodium

98%

80元/50mg; 210元/250mg; 520元/1g; 1280元/5g;

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储存：2-8°C
状态：浅橙色到黄色到绿色粉末到晶体

F0820

TCI

Fluvastatin Sodium Salt

>98.0%(HPLC)(N)

880元/1G; 2950元/5G;

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基本信息

纯度/分析方法	>98.0%(HPLC)(N)
分子式/分子量	C₂₄H₂₅FNNaO₄ = 433.46
外观与形状(20℃)	固体
储存温度	0-10℃
应避免的情况	加热
相关CAS RN	93957-54-1
PubChem物质ID	160870917
Merck Index (14)	4218
MDL编号	MFCD00929076

技术规格

Appearance	Light orange to Yellow to Green powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 98.0 %(calcd.on anh.substance)
Water	max. 6.0 %

物性(参考值)

溶解性(可溶于)

甲醇

相关法规

RTECS#

MJ9675100

Y0001082

Fluvastatin for system suitability

European Pharmacopoeia (EP) Reference Standard

1240.86元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 0.5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₄H₂₅FNNaO₄
分子量	433.45
MDL编号	MFCD08063391
PubChem化学物质编号	329831252
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	[Na+].CC(C)n1c(\C=C\[C@H](O)C[C@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
InChI	1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1
InChI key	ZGGHKIMDNBDHJB-RPQBTBOMSA-M

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1285931

USP

Fluvastatin sodium

United States Pharmacopeia (USP) Reference Standard

4292.37元/350 MG; 4292.37元/2 X 350 MG; 4292.37元/2 X 350 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₄H₂₅FNNaO₄
分子量	433.45
MDL编号	MFCD08063391
PubChem化学物质编号	329749905
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	[Na+].CC(C)n1c(\C=C\[C@H](O)C[C@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
InChI	1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1
InChI key	ZGGHKIMDNBDHJB-RPQBTBOMSA-M

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

SML0038

Sigma-Aldrich

Fluvastatin sodium hydrate

≥98% (HPLC)

1194.32元/10 MG; 4821.59元/50 MG;

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产品说明

应用

氟伐地汀钠水合物已被用于：

考察其对β -葡聚糖诱导的免疫驯化的作用
研究斯达汀对解偶联蛋白 (UCP1)⁺细胞数目的影响
确定其对星形胶质细胞胰岛素降解酶 (IDE) 分泌的影响
治疗并研究其对脐静脉内皮细胞 (HUVEC) 的体外作用

氟伐地汀钠水合物已被用于：

测试其抗丙肝病毒 (HCV) 活性
作为胆固醇抑制剂
研究其对β-葡聚糖诱导的单核细胞免疫驯化的作用

包装

10, 50 mg in glass bottle

生化/生理作用

氟伐地汀具有抗真菌活性。
氟伐他汀是羟甲基戊二酰辅酶A(HMG-CoA)还原酶的一种竞争性抑制剂，该酶可催化HMG-CoA转化为甲羟戊酸，而这是胆固醇生物合成中的限速步骤。氟伐他汀可抗血脂，能用于降低血浆胆固醇的水平并预防心血管疾病。

特点和优势

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

基本信息

经验(实验)分子式	C₂₄H₂₅FNO₄ · Na · xH₂O
分子量	433.45 (anhydrous basis)
MDL编号	MFCD20488050
PubChem化学物质编号	329825108
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to tan
溶解性	H₂O: ≥9 mg/mL
创始人	Novartis
储存温度	2-8℃
SMILES string	O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
InChI	1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1
InChI key	KKEMYLLTGGQWCE-PMRANXHDSA-M

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

PHR1620

Supelco

Fluvastatin sodium

Pharmaceutical Secondary Standard; Certified Reference Material

1728.67元/1 G;

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产品说明

一般描述

Fluvastatin sodium is a lipid-lowering drug that belongs to the group of compounds known as statins. It acts by inhibiting the enzyme HMG-CoA reductase that plays a key role in the cholesterol production. It is generally used to reduce plasma cholesterol levels and prevent cardiovascular disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Fluvastatin sodium may be used as a reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

附注

To see an example of a Certificate of Analysis for this material enter LRAA5290 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₂₄H₂₅FNNaO₄
分子量	433.45
MDL编号	MFCD08063391
PubChem化学物质编号	329823514
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
包装	ampule of 1 × 1 g
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to PhEur Y0001082 traceable to USP 1285931
储存温度	2-30℃
SMILES string	[Na+].CC(C)n1c(\C=C\[C@H](O)C[C@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
InChI	1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1
InChI key	ZGGHKIMDNBDHJB-RPQBTBOMSA-M

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0001090

Fluvastatin sodium

European Pharmacopoeia (EP) Reference Standard

1572.27元/ ;

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产品说明

一般描述

包装

Unit quantity: 110 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₄H₂₅FNNaO₄
分子量	433.45
MDL编号	MFCD08063391
PubChem化学物质编号	329831258
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	[Na+].CC(C)n1c(\C=C\[C@H](O)C[C@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
InChI	1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1
InChI key	ZGGHKIMDNBDHJB-RPQBTBOMSA-M

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

BP1163

Fluvastatin sodium

British Pharmacopoeia (BP) Reference Standard

2189.77元/100 MG;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₄H₂₅FNNaO₄
分子量	433.45
MDL编号	MFCD08063391
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	[Na+].CC(C)n1c(\C=C\[C@H](O)C[C@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
InChI	1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1
InChI key	ZGGHKIMDNBDHJB-RPQBTBOMSA-M

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

344096

Sigma-Aldrich

InSolution Fluvastatin, Sodium Salt-CAS 93957-55-2-Calbiochem

A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent.

1763.65元/10 MG;

咨询

产品说明

一般描述

A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.

包装

10 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Reversible: yes

警告

Toxicity: Standard Handling (A)

外形

A 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.

其他说明

Yamamoto, A., et al. 2001. J. Pharm. Pharmacol.53, 227.
Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol.52, 145.
Ikeda, U., et al. 2000. Hypertension36, 325.
Levy, R.I., et al. 1993. Circulation87 (4 Suppl.), III45.
Tse, F.L.S. et al. 1992. J. Clin. Pharmacol.32, 630.
Yuan, J., et al. 1991. Atherosclerosis87, 147.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₄H₂₅FNNaO₄
分子量	433.45
MDL编号	MFCD08063391

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze avoid repeated freeze/thaw cycles protect from light
运输	dry ice
储存温度	−70℃
InChI	1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1
InChI key	ZGGHKIMDNBDHJB-RPQBTBOMSA-M

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable