CAS 93839-89-5; 5'-(γ-硫代)三磷酸腺苷四锂盐; adenosine-5'-o-(3-thiotriphosphate)(atp-g-s),sodium salt

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CAS:

93839-89-5

分子式:

C₁₀H₁₂N₅O₁₂P₃S • ₄Li

分子量:

546.98

中文名称:

5'-(γ-硫代)三磷酸腺苷四锂盐

[腺苷-5'-(γ-硫代)]三磷酸四锂盐

英文名称:

adenosine-5'-o-(3-thiotriphosphate)(atp-g-s),sodium salt

adenosine-5'-o-(3-thiotriphosphate)(atp-g-s),sodiumsalt

Adenosine 5'-[γ-thio]triphosphate tetralithium salt;Ado-5'-PPP[S];ATP-γ-S;Adenosine 5'-(3-thiotriphosphate)trilithium salt

用途:

Adenosine 5'-(γ-thio)-triphosphate (lithium salt) is a stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors

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货号

品牌

产品名称

规格

包装、参考价格

详情

A913146

MACKLIN

Adenosine 5'-(γ-thio)-triphosphate (lithium salt)

98%

2203元/5mg; 4200元/10mg;

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储存：-20°C，密闭，干燥
状态：白色粉末

A1388

Sigma-Aldrich

Adenosine 5′-[γ-thio]triphosphate tetralithium salt

≥75% (HPLC), powder

1375.94元/1 MG; 3288.23元/5 MG; 8125.39元/25 MG;

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产品说明

应用

腺苷5′-[γ-硫代]三磷酸腺苷四锂盐已用于处理花粉粒，测定三磷酸腺苷(ATP)或其水解产物的抑制作用。它还用于筛选硫代磷酸酯靶蛋白。

包装

25 mg in poly bottle
1, 5 mg in glass bottle

生化/生理作用

腺苷5′-[γ-硫代]三磷酸(ATP-γ-S)是一种广泛使用的非水解ATP类似物，用于研究包括细胞外功能等多种过程中ATP结合ATP位点的影响。ATP- γ-S是一种P2嘌呤能激动剂，能够增强Ca²⁺-活化 K⁺通道活性。 ATP- γ-S能够在激酶反应中取代ATP，生成硫代磷酸化蛋白，耐受蛋白磷酸酶，调节泛素偶联物和26S蛋白酶体结合的ATP依赖性步骤。 ATP-γ -S可差分调节Toll样受体4介导的细胞存活和死亡。

其他说明

非水解ATP类似物

基本信息

经验(实验)分子式	C₁₀H₁₂Li₄N₅O₁₂P₃S
分子量	546.98
Beilstein	6265083
EC 号	298-862-8
MDL编号	MFCD00077293
eCl@ss	32160414
PubChem化学物质编号	24890536

产品性质

质量水平	200
测定	≥90% (HPLC)
形式	powder
颜色	white
溶解性	H₂O: 25 mg/mL
运输	dry ice
储存温度	−20℃
SMILES string	[Li+].[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
InChI	1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
InChI key	DWQFDOIBOYDYKH-KWIZKVQNSA-J

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

119120

Millipore

Adenosine 5'-O-(3-Thiotriphosphate), Tetralithium Salt-CAS 93839-89-5-Calbiochem

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

6181.82元/25 MG;

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产品说明

一般描述

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases the activity of Ca²⁺-activated K⁺ channels. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.
A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases activity of Ca²⁺-activated K⁺ channels. Used as an inhibitor of ATP-dependent enzyme systems.

包装

25 mg in Glass bottle

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.

其他说明

Troadec, J.D., et al. 1999. Pflugers Arch. 437, 745.
Chung, S., et al. 1991. Science253, 560.
Litosch, I., and Fain, J.N. 1986. Life Sci. 39, 187.
Chrysogelos, S., et al. 1983. J. Biol. Chem.258, 12624.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₀H₁₂N₅O₁₂P₃S · 4Li
分子量	546.98
MDL编号	MFCD00077293

产品性质

质量水平	100
测定	≥85% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic)
杂质	<10% ADP
颜色	white
溶解性	water: 10 mg/mL
运输	wet ice
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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