CAS 93718-83-3; 2,3-双[(2-羟乙基)硫代] -1,4-萘醌; nsc 95397

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CAS:

93718-83-3

分子式:

C₁₄H₁₄O₄S₂

分子量:

310.380

中文名称:

2,3-双[(2-羟乙基)硫代] -1,4-萘醌

英文名称:

nsc 95397

2,3-bis[(2-hydroxyethyl)thio]-1,4-naphthoquinone

用途:

A potent, selective, reversible Cdc25 dual specificity phosphatase inhibitor with Ki of 32/96/40 nM for Cdc25A/B/C, respectively.

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

N910278

MACKLIN

NSC95397

98%

774元/100mg; 1379元/250mg;

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储存：-20°C，密闭，干燥

N798114

MACKLIN

NSC95397

10mM in DMSO

230元/1ml;

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储存：-20°C

N1786

Sigma-Aldrich

NSC 95397

≥97% (HPLC)

1573.27元/5 MG;

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产品说明

包装

5 mg in glass bottle

生化/生理作用

不可逆Cdc25双特异性磷酸酶抑制剂。

基本信息

经验(实验)分子式	C₁₄H₁₄O₄S₂
分子量	310.39
MDL编号	MFCD04040032
PubChem化学物质编号	24278484
NACRES	NA.77

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	powder
颜色	orange, solid
溶解性	DMSO: 16 mg/mL
储存温度	−20℃
SMILES string	OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O
InChI	1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
InChI key	MAASHDQFQDDECQ-UHFFFAOYSA-N
Gene Information	human ... CDC25A(993), CDC25B(994), CDC25C(995)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

217694

Sigma-Aldrich

Cdc25 Inhibitor IV, NSC 95397-CAS 93718-83-3-Calbiochem

The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor

1954.93元/10 MG;

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产品说明

一般描述

A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (K_i = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G₂M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC₅₀ = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Dulyaninova, N.G., et al. 2011. Biochemistry50, 7218.
Lazo, J.S., et al. 2002. Mol. Pharmacol.61, 720.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₄H₁₄O₄S₂
分子量	310.39
MDL编号	MFCD04040032

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	orange
溶解性	DMSO: 100 mg/mL, clear, red
运输	ambient
储存温度	2-8℃
SMILES string	O=C1C(SCCO)=C(SCCO)C(C2=CC=CC=C21)=O
InChI	1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
InChI key	MAASHDQFQDDECQ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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