CAS 93076-89-2; r 59022

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R933220

MACKLIN

R 59-022

≥98%

1298元/5mg; 1952元/10mg; 3791元/25mg;

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储存：-20°C，惰性气体保存

D5919

Sigma-Aldrich

Diacylglycerol Kinase Inhibitor I

solid

1538.08元/1 MG; 5191.03元/5 MG;

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产品说明

一般描述

二酰基甘油激酶抑制剂I可防止异物巨细胞(FBGC)的形成。它可抑制二酰基甘油磷酸化为磷脂酸。二酰基甘油激酶抑制剂I可充当血清素(5-HT)受体(5-HTR)拮抗剂。它可刺激神经元细胞系NG108-15的凋亡和自噬。

应用

二酰基甘油激酶抑制剂I已被用作抑制剂用于使用高世代人类CAR(嵌合抗原受体)T细胞研究T细胞功能的抑制作用。

包装

1, 5 mg in glass bottle

生化/生理作用

二酰基甘油激酶抑制剂。抑制红细胞膜中[³⁸P]1-油酰基-2-乙酰甘油基-3-磷酸(OAPA)的形成：IC₅₀ = 3.3 μM。

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDF D5919.pdf 中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息，请访问sigma.com/metlin。

基本信息

经验(实验)分子式	C₂₇H₂₆FN₃OS
分子量	459.58
MDL编号	MFCD00055114
PubChem化学物质编号	24893986
NACRES	NA.77

产品性质

质量水平	200
生物来源	synthetic (organic)
测定	≥98% (HPLC)
形式	solid
颜色	pale yellow
溶解性	0.1 M HCl: slightly soluble 0.1 M NaOH: slightly soluble DMSO: soluble H₂O: insoluble ethanol: soluble ethyl acetate: soluble
储存温度	−20℃
SMILES string	CC1=C(CCN2CCC(\CC2)=C(\c3ccccc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1
InChI	1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
InChI key	MFVJXLPANKSLLD-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

266785

Sigma-Aldrich

Diacylglycerol Kinase Inhibitor I-CAS 93076-89-2-Calbiochem

The Diacylglycerol Kinase Inhibitor I, also referenced under CAS 93076-89-2, controls the biological activity of Diacylglycerol Kinase. This small molecule/inhibitor is primarily used for Phosphorylat

2165.23元/5 MG;

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产品说明

一般描述

Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC₅₀ = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Potentiates this effect in studies of signal-transducing inositol lipid metabolism. Inhibits human platelet DAG kinase in intact cells (IC₅₀ = 3.6 µM) and in isolated membranes (IC₅₀ = 6.7 µM). In porcine thymus cytosol it inhibits the 80 kDa DAG kinase (IC₅₀ = 10 µM) but has no effect on the 150 kDa DAG kinase. Weak dopamine D₂ and histamine H₁ antagonist and strong serotonin-S₂ antagonist.
Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC₅₀ = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Weak dopamine D₂ and histamine H₁ antagonist and strong serotonin S₂ antagonist.

包装

5 mg in Plastic ampoule

生化/生理作用

Primary Target
Diacylglycerol Kinase
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.

其他说明

Goin, M., et al. 1993. FEBS Lett. 316, 68.
Ohtsuka, T., et al. 1990. J. Biol. Chem.265, 15418.
de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem.260, 15762.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₇H₂₆FN₃OS
分子量	459.58
MDL编号	MFCD00055114

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	ethanol: 12 mg/mL DMSO: 4 mg/mL
运输	ambient
储存温度	10-30℃
InChI	1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
InChI key	MFVJXLPANKSLLD-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable