| CAS: | 929095-18-1 | |
| 分子式: | C27H28F3N5O2S | |
| 分子量: | 543.6 | |
| 英文名称: |
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| 用途: | GSK461364抑制纯化的Plk1，无细胞试验中Ki为2 nM。比作用于Plk2/3选择性高1000倍。Phase 1。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||
| G795074 | MACKLIN | GSK461364 | 10mM in DMSO | 456元/1ml; | 展开 | ||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||
| G873280 | MACKLIN | GSK461364 | 99% | 575元/25mg; 1268元/100mg; | 展开 | ||||||||||||||||||||||||||||||||
储存：-20℃ 状态：粉末 | |||||||||||||||||||||||||||||||||||||
| 1018989 | J&K | GSK461364 | 98%, 一种有效的 Polo-like kinase 1 抑制剂 | 1995元/10MG; | 展开 | ||||||||||||||||||||||||||||||||
基本信息
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| SML1912 | Sigma-Aldrich | GSK461364A | ≥98% (HPLC) | 1746.67元/5 MG; 5643.95元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||
产品说明 生化/生理作用 GSK461364 is an imidazotriazine derivate that inhibits polo-like kinase 1 (Plk1) in a potent, reversible, ATP-competitive, and highly selective manner (Kiapp <0.5 nM vs. 0.86 μM for Plk2 and 200 μM for Plk3; ATP Kmapp = 16 μM), exhibiting much reduced or little potency toward a panel of 262 kinases. GSK461364A inhibits the growth of various cancer cultures (IG50 <100 nM) as a result of either growth arrest (cytostasis) or cytotoxicity in vitro and effectively suppresses the expansion of various human tumor exnografts in mice in vivo (25 or 50 mg/kg i.p. q2dx12). 基本信息
产品性质
安全信息
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