CAS 924377-85-5; gsk-2934a

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CAS:

924377-85-5

英文名称:

gsk-2934a

gsk1702934a

1,3-dihydro-1-[1-[(5,6,7,8-tetrahydro-4h-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2h-benzimidazol-2-one

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货号

品牌

产品名称

规格

包装、参考价格

详情

SML2323

Sigma-Aldrich

GSK1702934A

≥98% (HPLC)

944.89元/5 MG; 3816.61元/25 MG;

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产品说明

生化/生理作用

GSK1702934A (GSK-2934A) is a direct activator of TRPC3 and TRPC6 ion channels with selectivity for TRPC3. In HEK293 kidney cells transduced with recombinant human TRPC3 or TRPC6, GSK1702934A activated current with an EC50 of ∼ 80 nM for TRPC3 vs. 440 nM for TRPC6. It does not activate TRPV4, TRPA1, M1, M4, CaV1.2, hERG, NaV1.5, or CXCR5 receptors at concentrations <10 μM. GSK1702934A has been used to study TRPC3 channels in the heart, exhibiting pro-arrhythmic, and inotropic actions in isolated Langendorff hearts from TRPC3-overexpressing mice.

基本信息

经验(实验)分子式	C₂₂H₂₅N₃O₂S
分子量	395.52
MDL编号	MFCD08868156
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C1N(C2CCN(C(C3=CC(CCCCC4)=C4S3)=O)CC2)C5=CC=CC=C5N1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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