| CAS: | 911222-45-2 | |
| 分子式: | C18H22BrN5O3 | |
| 分子量: | 436.30 | |
| 英文名称: |
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| 用途: | Y2603618是一种选择性Chk1抑制剂，具有潜在的抗肿瘤活性。Phase 2。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||
| L863983 | MACKLIN | LY2603618 | 98% | 224元/5mg; 650元/25mg; | 展开 | ||||||||||||||||||||||||||||||
储存：-20°C 状态：灰白色到黄色固体 | |||||||||||||||||||||||||||||||||||
| L796326 | MACKLIN | LY2603618 | 10mM in DMSO | 805元/1ml; | 展开 | ||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||
| SML2855 | Sigma-Aldrich | LY2603618 | ≥98% (HPLC) | 833.87元/5 MG; 3365.56元/25 MG; | 展开 | ||||||||||||||||||||||||||||||
产品说明 生化/生理作用 LY2603618 (LCI-1) is a potent and selective checkpoint kinase 1 (Chk1) inhibitor (IC50 = 7 nM) that produces a cellular phenotype identical to that reported upon Chk1 depletion by RNAi. LY2603618 prevents doxorubicin-induced Chk1 autophosphorylation (IC50 = 52 nM; HeLa), allowing cells to traverse the G2/M checkpoint and proceed into mitosis with unresolved replicated chromosomes. LY2603618 renders mutant p53, but not wild-type, HT-29 colon cancer cells more sensitive to gemcitabine both in vitro and in mice in vivo. 基本信息
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