| CAS: | 905973-89-9 | ||
| 分子式: | C23H18Cl3FN4O3S | ||
| 分子量: | 555.84 | ||
| 英文名称: |
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| 用途: | CGK733是ATM/ATR选择性抑制剂，IC50为200 nM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||
| C793159 | MACKLIN | CGK733 | 10mM in DMSO | 620元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||
| C860859 | MACKLIN | CGK733 | 98% | 367元/10mg; 1060元/50mg; 2050元/100mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||
储存：-20℃ 状态：浅黄色固体 折射率：light yellow solid | |||||||||||||||||||||||||||||||||||||||||||
| 1564012 | J&K | CGK733 | 98%, 一种有效的 ATM/ATR 抑制剂 | 1029元/10MG; 3291元/50MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||
基本信息
产品描述 CGK 733是一种有效的ATM/ATR选择性抑制剂，IC50约为200 nM。 靶点（IC50 & Targe） ATM ATR 体外研究 CGK 733能够使已经停止增殖的衰老细胞强劲生长。CGK 733处理的细胞中，与衰老相关的β-半乳糖苷酶（SA–β-gal）活性消失。CGK 733比LY294002(抑制ATM 和 ATR，IC50约为5 μM)更有效抑制ATM/ATR（IC50〜5微米ATM和ATR），是PI3K和PIKKs的泛抑制剂。[1] CGK 733 (30 μM)处理衰老的MCF-7细胞24小时，造成约60%细胞死亡。[2]CGK 733（20μM）作用于MCF-7和 T47D乳腺癌细胞系，通过泛素-蛋白酶体降解途径，诱导cyclin D1损失。CGK 733浓度范围为0.6-40 μM时，抑制MCF-7 和 T47D 雌激素受体 (ER) 阳性的乳腺癌细胞, MDA-MB436 ER 阴性的乳腺癌细胞, LnCap前列腺癌细胞，和 HCT116结肠癌细胞增殖。此外，CGK 733也抑制非转化的小鼠BALB/c 3T3胚胎成纤维细胞增殖。CGK 733-介导的抑制增殖作用是剂量依赖性的，剂量低至2.5 μM效果显著。[3] 细胞实验 Cell lines: 人类乳腺癌细胞 MCF-7 Concentrations: ～20 μM Incubation Time: 2 天 Method: 细胞按预定的最佳细胞密度接种于96孔板中，确保在实验期间细胞呈指数生长状态。预温育24小时后，使用含适当浓度药物，或0.1% (v/v) 空白对照的实验培养基更换生长培养基。培养48小时后，使用Sulforhodamine B比色法测评细胞增殖。 (Only for Reference) 参考文献 [1] Won J, et al. Nat Chem Biol, 2006, 2(7), 369-374. [2] Crescenzi E, et al. Clin Cancer Res, 2008, 14(6), 1877-1887. [3] Alao JP, et al. Radiat Oncol, 2009, 4:51. 安全信息
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| 118501 | Sigma-Aldrich | ATM/ATR Kinase Inhibitor-CAS 905973-89-9-Calbiochem | The ATM/ATR Kinase Inhibitor, also referenced under CAS 905973-89-9, controls the biological activity of ATM/ATR Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Depho | 3806.77元/5 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC50 = ~200 nM) without significant effect against other PIKK family members (PI 3-K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI 3-K/PDK1/Akt signaling pathway. 包装 5 mg in Plastic ampoule 生化/生理作用 Cell permeable: yes 警告 Toxicity: Irritant (B) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Goldstein, M., et al. 2008. Toxicol. Appl. Pharmacol.in press. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
产品性质
安全信息
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| C9867 | Sigma-Aldrich | CGK733 | ≥98% (HPLC), solid | 1445.69元/5 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||
产品说明 包装 5 mg in glass bottle 生化/生理作用 Originally published as a selective ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) kinase inhibitor, which causes reversible reprogramming of cellular lifespan, conferred robust growth to senescent cells that had ceased proliferation. 基本信息
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