CAS 90417-38-2; nu-1025

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货号

品牌

产品名称

规格

包装、参考价格

详情

N872890

MACKLIN

NU1025

99%

588元/5mg;

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储存：-20℃
状态：粉末

252838

J&K

8-Hydroxy-2-methylquinazoline-4-one

97%

4062元/10MG; 16214元/50MG;

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基本信息

分子式	C₉H₈N₂O₂
分子量	176.17
熔点	253-258
MDL编码	MFCD00942555
存储条件	Freezer -20℃

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H319
防范说明	P305+P351+P338
WGK	3

493800

Sigma-Aldrich

PARP Inhibitor VI, NU1025-CAS 90417-38-2-Calbiochem

The PARP Inhibitor VI, NU1025, also referenced under CAS 90417-38-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

2846.26元/5 MG;

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产品说明

一般描述

A potent inhibitor poly(ADP-ribose) polymerase (PARP; IC₅₀ = 0.40 µM). Has been shown to potentiate the cytotoxicity of the DNA-methylating agent MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide] and ionizing irradiation in murine L210 leukemia cells.
A potent poly(ADP-ribose) polymerase (PARP) inhibitor (IC₅₀ = 400 nM) that potentiates the cytotoxicity of various DNA-active agents, including the DNA-methylating compound MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide], the DNA strand break-inducing drug temozolomide, topotecan, bleomycin, and ionizing radiation in murine L1210 leukemia cells, Chinese hamster ovary cells, and in a variety of human tumor cell lines.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
PARP
Reversible: no
Cell permeable: no
Target IC₅₀: 0.4 µM against poly(ADP-ribose) polymerase (PARP)

警告

Toxicity: Standard Handling (A)

制备说明

This solution can be further diluted 1:100 in tissue culture medium before use.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Delaney, C.A., et al. 2000. Clin. Cancer Res.6, 2860.
Boulton, S., et al. 1999. Carcinogenesis20, 199.
Bowman, K.J., et al. 1998. Br. J. Cancer 78, 1269.
Griffin, R.J., et al. 1998. J. Med. Chem. 41, 5247.
Griffin, R.J., et al. 1996. Pharm. Sci. 2, 43.
Boulton, S., et al. 1995. Br. J. Cancer 72, 849.
Griffin, R.J., et al. 1995. Anticancer Drug Res. 10, 507.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₉H₈N₂O₂
分子量	176.17
MDL编号	MFCD00942555

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	off-white
溶解性	DMSO: 25 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)
InChI key	YJDAOHJWLUNFLX-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

N7287

Sigma-Aldrich

NU-1025

≥97% (HPLC), solid

2475.02元/5 MG;

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产品说明

包装

5 mg in glass bottle

生化/生理作用

NU-1025 is a PARP inhibitor.

基本信息

经验(实验)分子式	C₉H₈N₂O₂
分子量	176.17
MDL编号	MFCD00942555
PubChem化学物质编号	24724555
NACRES	NA.77

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
颜色	off-white
溶解性	DMSO: soluble >20 mg/mL H₂O: insoluble
储存温度	−20℃
SMILES string	CC1=Nc2c(O)cccc2C(=O)N1
InChI	1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)
InChI key	YJDAOHJWLUNFLX-UHFFFAOYSA-N
Gene Information	mouse ... Parp2(11546)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves