| CAS: | 896466-04-9 | |
| 分子式: | C19H23N7O2 | |
| 分子量: | 381.43 | |
| 中文名称: |
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| 英文名称: |
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| 用途: | AT9283是一种有效的JAK2/3抑制剂，无细胞试验中IC50为1.2 nM/1.1 nM；对Aurora A/B，Abl(T315I)也有效。Phase 2。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||
| C872676 | MACKLIN | 1-环丙基-3-(3-(5-(吗啉甲基)-1H-苯并[d]咪唑-2-基)-1H-吡唑-4-基)脲 | 99% | 269元/1mg; 500元/5mg; 900元/10mg; 1250元/25mg; 3400元/100mg; | 咨询 | ||||||||||||||||||||||||||
储存：-20℃ 状态：白色到米黄色粉末 | |||||||||||||||||||||||||||||||
| C793878 | MACKLIN | 1-环丙基-3-(3-(5-(吗啉甲基)-1H-苯并[d]咪唑-2-基)-1H-吡唑-4-基)脲 | 10mM in DMSO | 891元/1ml; | 咨询 | ||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||
| SML2394 | Sigma-Aldrich | AT9283 | ≥98% (HPLC) | 995.52元/5 MG; 3215.2元/25 MG; | 咨询 | ||||||||||||||||||||||||||
产品说明 生化/生理作用 AT9283 is an ATP site-targeting pyrazole-benzimidazole-based molecule with inhibitory potency against multiple kinases, most notably Aurora A/B (IC50 ≤3.0 nM), JAK2/3 (IC50 = 1.2/1.1 nM), Abl T315I (IC50 = 4 nM), GSK3β, FGFR2, VEGFR3 (Flt4), Mer, Ret, Rsk2/3, Tyk2, Yes (IC50 = 1-10 nM). AT9283 also inhibits 72 other kinases/mutations at a reduced potency (IC50 = 10-30 nM against 14, 30-100 nM against 21, 100-300 against 37 targets), while displaying an IC50 >300 nM toward 144 other kinase targets. AT9283 inhibits the growth/survival of multiple solid tumor cell lines in vitro (IC50 = 7.7-20 nM) and shows anti-cancer efficacy in mice via i.p. injection in vivo (67% and 76%HCT116 tumor growth inhibition on day 16, respectively, with 15 and 20 mg/kg b.i.d., two-day on and two-day off; >95% inhibition of Ba/F3 ETV6-JAK2 leukemia proliferation on day 12 with 10 mg/kg b.i.d. on days 2–5 and 8–12). 基本信息
产品性质
安全信息
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| 230843 | Fluorochem | 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea | 95% | 9746元/250mg; 24046元/1g; | 咨询 | ||||||||||||||||||||||||||
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