CAS 894187-61-2; stf-118804

CAS:

894187-61-2

分子式:

C₂₅H₂₃N₃O₄S

分子量:

461.53

英文名称:

stf-118804

4-[5-methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-n-(3-pyridinylmethyl)-benzamide

stf 118804

4-(5-methyl-4-(tosylmethyl)oxazol-2-yl)-n-(pyridin-3-ylmethyl)benzamide

用途:

STF-118804是高特异性NAMPT抑制剂。STF-118804降低包含MLL染色体翻译的B-ALL细胞系的活性， IC50值在毫微摩尔级范围。此外，取自5个小儿科ALL患者的白血病样品也对低毫微摩尔级范围的STF-118804敏感。STF-118804诱导白血病MV411细胞凋亡，而没有先前的细胞周期阻滞。[1]

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S872566

MACKLIN

STF-118804

98%

175元/10mg; 359元/25mg; 492元/50mg; 837元/100mg; 1591元/250mg;

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储存：-20℃
状态：粉末

S792317

MACKLIN

STF-118804

10mM in DMSO

720元/1ml;

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储存：-20°C

SML1348

Sigma-Aldrich

STF-118804

≥98% (HPLC)

1117.23元/5 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

STF-118804 is a highly specific and potent NAMPT (nicotinamide phosphoribosyl transferase) inhibitor that reduces the viability of most B-ALL cell lines. STF 118804 induces leukemia cell apoptosis including leukemia initiating (stem) cells. STF 118804 improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia.
STF-118804 displays pancreatic ductal adenocarcinoma (PDAC) growth reducing potential in combination with chemotherapeutic drugs.

基本信息

经验(实验)分子式	C₂₅H₂₃N₃O₄S
分子量	461.53
MDL编号	MFCD14918065
PubChem化学物质编号	329825804
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(C1=CC=C(C2=NC(CS(=O)(C3=CC=C(C)C=C3)=O)=C(C)O2)C=C1)NCC4=CN=CC=C4
InChI	1S/C25H23N3O4S/c1-17-5-11-22(12-6-17)33(30,31)16-23-18(2)32-25(28-23)21-9-7-20(8-10-21)24(29)27-15-19-4-3-13-26-14-19/h3-14H,15-16H2,1-2H3,(H,27,29)
InChI key	DLFCEZOMHBPDGI-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable