CAS 890888-12-7; s3qel 2

CAS:

890888-12-7

分子式:

C₁₉H₂₅N₅

分子量:

323.4

英文名称:

s3qel 2

1-(3,4-dimethylphenyl)-n,n-dipropyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine

用途:

S3QEL-2 is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site IIIQo superoxide production (IC50 = 1.7 µM) without altering normal bioenergetics function.

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S912971

MACKLIN

S3QEL-2

98%

679元/10mg;

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储存：-20°C，密闭，干燥

SML1554

Sigma-Aldrich

S3QEL 2

1217.65元/10 MG; 3943.82元/50 MG;

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产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

S3QEL 2, a cell permeable substituted allopurinol, is also known as 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.
S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation. Site IIIQo is the primary source of mitochondrial reactive oxygen species (ROS) and has been implicated in a broad range of ROS-mediated signaling and pathology. S3QEL 2 lowered HIF-1α induction, protected against ROS-induced, JNK-mediated cell stress in pancreatic beta-cells, and decreased the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.

基本信息

经验(实验)分子式	C₁₉H₂₅N₅
分子量	323.44
NACRES	NA.77

产品性质

形式	powder
质量水平	100
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear
储存温度	−20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable