CAS 890819-86-0; ml349

CAS:

890819-86-0

分子式:

C₂₃H₂₂N₂O₄S₂

分子量:

454.56

英文名称:

ml349

(5,5-dioxido-4h-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone

ml 349

ml-349

(5,5-dioxo-4h-thieno[4,5-c]thiochromen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone

用途:

ML349 是一个有效且特异的酰基蛋白硫酯酶 2 (APT-2) 抑制剂，其 Ki 值为 120 nM。ML349 也是 LYPLA2 的抑制剂，其 IC50 值为 144 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

M876720

MACKLIN

ML349

≥98%

1067元/5mg; 3300元/25mg;

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储存：2-8℃

SML1918

Sigma-Aldrich

ML349

≥98% (HPLC)

1396.09元/5 MG; 4498.97元/25 MG;

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产品说明

生化/生理作用

ML349 is a substrate-competitive, reversible and APT2-selective acyl-protein thioesterase (APT) inhibitor (IC₅₀/K_i = 510 nM/230 nM against APT2; IC₅₀ & K_i >10 μM against APT1). ML349 effectively inhibits cellular APT2 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT1. ML349 treatment (5 μM) is shown to restore palmitoylation and membrane localization of the multidomain scaffolding protein Scribble (Scrib) in MDCK cells overexpressing the epithelial-to-mesenchymal transcription factor (EMT-TF) Snail.

基本信息

经验(实验)分子式	C₂₃H₂₂N₂O₄S₂
分子量	454.56

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 3 mg/mL, clear (warmed)
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable