基本信息
| 分子式 | C21H25N3O4 |
| 分子量 | 383.44 |
| 存储条件 | Freezer -20℃ |
产品描述 WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM. IC50 value: 450 nM (Kd) Target: WDR5 in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5.
靶点（IC50 & Targe） WDR5,
体外研究 体内研究 激酶实验 细胞实验 动物实验 参考文献 [1]. Senisterra G, et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J. 2013 Jan 1;449(1):151-159.
安全信息
| 图形或危害标志 |   |
| 危险说明 | H302
H410 |
| 防范说明 | P264
P270
P273
P301+P312
P330
P391
P501 |
| UN号码 | 3077 |
| 危险分类 | 9 |
| 包装等级 | III |
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