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CAS: 89-25-8
分子式: C10H10N2O
分子量: 174.20
沸点: 287℃(265
熔点: 127-131℃
中文名称: 
苯基甲基-5-氮茂酮
1-苯基-3-甲基-5-吡唑啉酮
依达拉奉
3-甲基-1-苯基-2-吡唑啉-5-酮
1-苯基-3-甲基-5-吡唑酮
吡唑啉酮
1,3,5-吡唑酮
2,4-二氢-5-甲基-2-苯基-3H-吡唑-3-酮
3-甲基-1-苯基-5-吡唑啉酮
苯基甲基氮茂酮-[5]
吡唑啉
2,4-二氢-5-甲基-2-苯基
展开更多中文名
英文名称: 
Edaravone
3H-Pyrazol-3-one,2,4-dihydro-5-methyl-2-phenyl-
2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
3H-Pyrazol-3-one,2,4-dihydro-5-methyl-
3-Methyl-1-phenyl-2-pyrazoline-5-one
Monopyrazolone
3-Methyl-1-phenyl-2-pyrazolin-5-one
1-Phenyl-3-methyl-5-pyrazolone
2,4-dihydro-5-methyl-2-phenyl-3H-Pyrazol-3-one
3-methyl-1-phenyl-2-pyrazolin-5-on
1-fenyl-3-methyl-2-pyrazolin-5-on
1-phenyl-3-methyl-5-oxo-2-pyrazoline
1-phenyl-3-methylpyrazolone
1-phenyl-3-methylpyrazolone-5
3-methyl-1-phenyl-5-pyrazolone
2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-on
3-methyl-1-phenyl-5-pyrazolon
c.i. developer 1
ci developer 1
developer z
mci-186
nci-c03952
norantipyrine
norphenazone
phenylmethylpyrazolone
1-Phenyl-3-methyl-5-pyra zolon
展开更多英文名
性质描述: 白色结晶或粉末。熔点127℃,沸点287℃(35.3kPa)。溶于水、微溶于醇和苯,不溶于醚、石油醚及冷水。
生产方法: 苯肼与乙酰乙酸乙酯反应而得。将苯肼和乙醇加热至50℃左右,开始加入乙酰乙酸乙酯,加完后回流4h。稍冷后放置过夜析出黄色结晶,过滤,将粗品用乙醇重结晶即为成品。另一种制法是由苯肼与丁酮酰胺反应。将苯肼与丁酮酰胺在50℃左右反应,反应结束后过滤、水洗、干燥而得成品。原料消耗定额:苯胺(98%)560kg/t、液氨1100kg/t、盐酸(30%)1280kg/t、醋酸1060kg/t、硫酸(93%)840kg/t、硫磺850kg/t、亚硝酸铵(95%)440kg/t。
用途: 主要用于合成吡唑酮类解热镇痛药如安乃近、安替比林、氨基比林;也是吡唑酮类酸性染料如酸性媒介枣红BN、永固黄G以及彩色胶片染料、农药及及其他一些精细化学品的中间体。
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P794207MACKLIN1-苯基-3-甲基-5-吡唑啉酮10mM in DMSO302元/1ml;   展开
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基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C10H10N2O = 174.20
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气
Reaxys-RN609575
PubChem物质ID87572698
SDBS (AIST Spectral DB)2704
Merck Index (14)6713
MDL编号MFCD00003138

技术规格

AppearanceWhite to Orange to Green powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Neutralization titration)min. 98.0 %
Melting point128.0 to 131.0 ℃
Solubility in N,N-DMFalmost transparency
Suitability for cyan-analysisto pass test

物性(参考值)

熔点129 ℃
沸点287 ℃/265 mmHg
水溶性不溶
溶解性(微溶于)氯仿,二甲基甲酰胺,醇,苯

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#UQ9625000
343352J&K3-Methyl-1-phenyl-2-pyrazolin-5-one(Edaravone)98%, 高效自由基清除剂60元/5G;   209元/100G;   430元/500G;   展开

基本信息

分子式C10H10N2O
分子量174.20
熔点126-128
沸点287
MDL编码MFCD00003138
Beilstein609575
Merck14,6713
EINECS 编号201-891-0

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
H335
防范说明P261
P305+P351+P338
RTECSUQ9625000
TSCA
A11161Alfa Aesar3-Methyl-1-phenyl-2-pyrazolin-5-one98+%358元/100g;   630元/500g;   2703元/2500g;   展开

应用
3-Methyl-1-phenyl-2-pyrazolin-5-one used as reagent for detection of reducing carbohydrates by ESI/MALDI -MS.

备注
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

基本信息

MDL
MFCD00003138

EINECS
201-891-0

分子式
C10H10N2O

分子量
174.20

熔点
127-131°

沸点
191°/17mm

密度
1.120

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water(3.3g/L).

Beilstein
609575

Merck
14,6713

GHS危害和防范说明

GHS符号

Hazard Statements
H302
Harmful if swallowed.

Precautionary Statements
P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Do not eat, drink or smoke when using this product.Rinse mouth.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22
Harmful if swallowed.

安全等级
36-60
Wear suitable protective clothing.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
UQ9625000

TSCA

C12746Alfa Aesar3-Methyl-1-phenyl-2-pyrazolin-5-one99%380元/5g;   413元/100g;   1005元/500g;   展开

基本信息

Ref#
12746

MDL
3138

分子式
C10 H10 N2 O

分子量
174.2

Y0001138Phenazone impurity AEuropean Pharmacopoeia (EP) Reference Standard1259.15元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C10H10N2O
分子量174.20
Beilstein609575
MDL编号MFCD00003138
PubChem化学物质编号329830780
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
bp287 ℃/265 mmHg (lit.)
mp126-128 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC1=NN(C(=O)C1)c2ccccc2
InChI1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
InChI keyQELUYTUMUWHWMC-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
1040016USPAntipyrine Related Compound AUnited States Pharmacopeia (USP) Reference Standard11011.4元/25 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C10H10N2O
分子量174.20
Beilstein609575
MDL编号MFCD00003138
PubChem化学物质编号329749047
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
bp287 ℃/265 mmHg (lit.)
mp126-128 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC1=NN(C(=O)C1)c2ccccc2
InChI1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
InChI keyQELUYTUMUWHWMC-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
M70800Sigma-Aldrich3-Methyl-1-phenyl-2-pyrazoline-5-one99%132.5元/5 G;   435.28元/100 G;   855.52元/500 G;   展开

产品说明

应用

3-甲基-1-苯基-2-吡唑啉-5-酮可用于:

  • ESI/MALDI-MS检测还原性碳水化合物的试剂
  • 提高还原性单糖和寡糖的敏感性,便于随后用毛细管区带电泳进行测定
  • 在用高效液相色谱(HPLC)分析之前,对 丹参、盐酸川芎嗪和葡萄糖注射液中单糖组分进行柱前衍生化。

ESI/MALDI -MS检测还原性碳水化合物的试剂。

包装

5, 100, 500 g in glass bottle

基本信息

经验(实验)分子式C10H10N2O
分子量174.20
Beilstein609575
EC 号201-891-0
MDL编号MFCD00003138
PubChem化学物质编号24897140
NACRESNA.22

产品性质

质量水平200
测定99%
bp287 ℃/265 mmHg (lit.)
mp126-128 ℃ (lit.)
application(s)peptide synthesis
SMILES stringCC1=NN(C(=O)C1)c2ccccc2
InChI1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
InChI keyQELUYTUMUWHWMC-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
443300Sigma-AldrichMCI-186-CAS 89-25-8-CalbiochemA free radical scavenger and antioxidant that reduces post-ischemic brain injury.1113.94元/500 MG;   展开

产品说明

一般描述

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.
A free radical scavenger and antioxidant that reduces post-ischemie brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.

包装

500 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Reversible: no
Target IC50: 15 µM inhibiting iron-dependent peroxidation in rat brain homogenates
Cell permeable: no
Primary Target
A free radical scavenger and antioxidant

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Katare, R. G., et al. 2003. Am. J. Physiol.285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C10H10N2O
分子量174.20
MDL编号MFCD00003138

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 cream
溶解性DMSO: 100 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
InChI keyQELUYTUMUWHWMC-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
038216Fluorochem3-Methyl-1-phenyl-2-pyrazoline-5-one95%220元/5g;   440元/250g;   792元/500g;   3476元/2.5kg;   展开

基本信息

CAS Number89-25-8
MDL NumberMFCD00003138
Melting Point129℃

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H411: Toxic to aquatic life with long lasting effects.
防范说明 P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P272: Contaminated work clothing should not be allowed out of the workplace.
P273: Avoid release to the environment.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P391: Collect spillage.
P501: Dispose of contents/container to in accordance with local regulation .
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