| CAS: | 88965-00-8 | |
| 分子式: | C15H14N2 | |
| 分子量: | 222.29 | |
| 中文名称: |
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| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||
| M916661 | MACKLIN | 6-甲基-2-(4-甲基苯基)咪唑[1,2-a]吡啶 | 98% | 121元/5g; 603元/25g; 2406元/100g; | 咨询 | ||||||||||||||||||||||||||
储存：室温 | |||||||||||||||||||||||||||||||
| SML2886 | Sigma-Aldrich | O4I3 | ≥98% (HPLC) | 623.38元/5 MG; 2521.28元/25 MG; | 咨询 | ||||||||||||||||||||||||||
产品说明 生化/生理作用 O4I3 is a highly potent and KDM5A (JARID1A) subtype-selective H3K4 demethylase KDM5 inhibitor (KDM5A IC50 = 0.15 nM vs KDM5B/C/D IC50 = 125.2/9.76/4.7 nM, KDM4 IC50 = 249 nM, LSD1 IC50 >100 μM) that effectively induces OCT4 expresson and improves OSKM-induced pluripotent stem cell (iPSC) reprogramming efficiency of human primary fibroblasts (50 nM) by preventing KDM5A from interfering with H3K4Me3 enrichment at the OCT4 promoter. O4I3 promotes hPSC homeostasis and represses cellular differentiation, increasing hPSCs viability up to 4-fold at a low 10 nM concentration when compared with Rock inhibitor Y-27632 treatment at 10 μM. 基本信息
产品性质
安全信息
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| 040705 | Fluorochem | 6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridine | 97% | 1650元/1g; 4906元/5g; 17160元/25g; | 咨询 | ||||||||||||||||||||||||||
基本信息
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