CAS 88495-63-0; 青蒿琥酯; Artemeter

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

A797763

MACKLIN

青蒿琥酯

10mM in DMSO

330元/1ml;

展开

储存：-20°C
状态：液体

A800614

MACKLIN

青蒿琥酯

99%

32元/1g; 79元/5g; 256元/25g; 916元/100g; 3713元/500g;

展开

储存：室温
状态：白色到浅黄色粉末

A2191

TCI

Artesunate

>98.0%(T)(HPLC)

550元/5G; 1490元/25G;

展开

基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₁₉H₂₈O₈ = 384.43
外观与形状(20℃)	固体
储存温度	0-10℃
应避免的情况	加热
Reaxys-RN	6003212
PubChem物质ID	87560999
Merck Index (14)	818
MDL编号	MFCD00866204

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Neutralization titration)	min. 98.0 %
Melting point	132.0 to 137.0 ℃
Specific rotation [a]20/D	+4.5 to +6.5 deg(C=1, CH2Cl2)

物性(参考值)

熔点	133 ℃
比旋光度 [α]D	5.5° (C=1,CH2Cl2)
溶解性(可溶于)	甲醇

安全信息

图形或危害标志
信号词	警告
危险性说明	H302 : 吞咽有害。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

173925

J&K

Artesunate

98%, 是 STAT-3 和输出蛋白 1 (EXP1) 的抑制剂

466元/5G; 1387元/25G;

展开

基本信息

分子式	C₁₉H₂₈O₈
分子量	384.42
熔点	132-135
MDL编码	MFCD00866204

产品描述

Artesunate 是一种抗疟类药，作用于小细胞肺癌细胞系H69，IC50为< 5 μM。它是一种潜在的STAT3抑制剂，在体外对癌细胞有选择性细胞毒性作用；是有效的EXP1抑制剂。

靶点（IC50 & Targe）

STAT

体外研究

ART could alter the biomechanical properties of the glioma cells to inhibit cell proliferation, migration and invasion [2]. The ART significantly suppresses the cell proliferation, induces the apoptosis and promoted cell cycle arrest at G0/G1 phase in SKM-1 cells. The mechanisms of ART anti-MDS is associated with the increase of intracellular calciumion concentration and ROS levels. In addition, the pro-apoptotic activity of ART may be involved in the regulation of BCL-2 /BAX ratio and the expressions of P-bad and survivin[3]. ART treatment demethylates CDH1, which, in turn recovers the E-cadherin activation in SKM-1 cells[1].

体内研究

Artesunate is a medication used to treat malaria. Artesunate can induce radiosensitivity of HeLa cells in vivo using Xenograft model of nude mice[5]. Artesunate had a relatively high immunosuppressive activity with low toxicity, and could inhibit T lymphocyte proliferation induced by mitogen and alloantigen[6].

细胞实验

Cell lines: SKM-1 cells

Concentrations: 0, 12.5, 25, 50 µg/mL

Incubation Time: 0, 24, 48, and 72 h

Method:Growth inhibition assay: The SKM-1 cells (1×105/mL) are firstly seeded in 96-well plates. Artesunate is diluted in 0.1% dimethyl sulfoxide (DMSO) producing 0, 12.5, 25, 50µg/mL concentrations and added to the SKM-1 cells with 100 µl per well. A negative control is treated with 0.1% DMSO. At 0, 24, 48, and 72 hours, same amount of MTT solution is added into each well and cultured for extra 4 hours. MTT treated cells are fixed with 150 µL DMSO for 30 min at room temperature and then determined with Evolution 201 and 220 UV-Vis spectrophotometer system at 540 nm.

(Only for Reference)

动物实验

Animal Models: BALB/c mice

Formulation: Dissolved in DMSO and diluted with sterile PBS

Dosages: 100 mg/kg/day

Administration: i.p.

(Only for Reference)

参考文献

[1] Xu N, et al. Int J Med Sci. 2015, 12(6):524-529.

[2] Lian S, et al. Oncol Rep. 2016, 36(2):984-990.

[3] Qiao SK, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016, 24(1):131-137.

[4] Lisewski AM, et al. Cell. 2014, 158(4):916-928.

[5] Luo J, et al.Radiat Oncol. 2014, 9:84.

[6] Li T, et al. Int Immunopharmacol. 2013, 16(2):306-312.

[7] Ilamathi M, et al. Curr Top Med Chem. 2016, 16(22):2453-63.

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H312 H332
防范说明	P280
WGK	3

C46034

Alfa Aesar

Artesunate

978元/5g; 3772元/25g;

展开

基本信息

Ref#
46034

分子式
C19H28O8

分子量
45.88

GHS危害和防范说明

GHS符号

Hazard Statements
H302 H312 H332

Precautionary Statements
P280 P302+P352 P312 P304+P340

A3731

Sigma-Aldrich

Artesunate

from Artemisia annua

4250.08元/100 MG; 7115.89元/500 MG;

展开

产品说明

一般描述

青蒿琥酯是青蒿素的半合成衍生物，用于治疗疟疾。它也被证明对其他寄生虫(如肝吸虫)有效。青蒿琥酯还显示出针对不同肿瘤类型的癌细胞系的细胞毒性作用。

包装

100, 500 mg in poly bottle

生化/生理作用

青蒿琥酯可作用于电子传递链，产生局部活性氧，引起线粒体膜的去极化。它可通过抑制人类风湿关节炎成纤维样滑膜细胞中的NF-κB和 PI3 激酶/Akt信号通路，抑制TNF诱导的促炎细胞因子的产生。

其他说明

将容器紧紧地封闭在干燥通风良好的地方。保存在干燥的地方。

基本信息

经验(实验)分子式	C₁₉H₂₈O₈
分子量	384.42
NACRES	NA.85

产品性质

生物来源	Artemisia annua
质量水平	100
形式	crystalline powder
颜色	white to off-white
溶解性	acetone: 33.4 mg/mL
作用机制	protein synthesis \| interferes
抗生素抗菌谱	neoplastics parasites
储存温度	room temp
InChI	1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18?,19-/m1/s1
InChI key	FIHJKUPKCHIPAT-JQXDXKTESA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332
预防措施声明	P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

PHR2573

Supelco

Artesunate

Pharmaceutical Secondary Standard; Certified Reference Material

2141.29元/300 MG;

展开

产品说明

一般描述

青蒿琥酯是青蒿素的半合成衍生物，用于治疗疟疾。它也被证明对其他寄生虫(如肝吸虫)有效。青蒿琥酯还显示出针对不同肿瘤类型的癌细胞系的细胞毒性作用。
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC6146 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₁₉H₂₈O₈
分子量	384.42

产品性质

等级	certified reference material pharmaceutical secondary standard
形式	solid
CofA	current certificate can be downloaded
包装	pkg of 300 mg
药典可追溯性	traceable to USP 1042850
储存温度	2-8℃
InChI	1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18?,19-/m1/s1
InChI key	FIHJKUPKCHIPAT-JQXDXKTESA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332
预防措施声明	P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1042850

USP

Artesunate

United States Pharmacopeia (USP) Reference Standard

3231.47元/200 MG;

展开

产品说明

一般描述

青蒿琥酯是青蒿素的半合成衍生物，用于治疗疟疾。它也被证明对其他寄生虫(如肝吸虫)有效。青蒿琥酯还显示出针对不同肿瘤类型的癌细胞系的细胞毒性作用。
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₉H₂₈O₈
分子量	384.42
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
InChI	1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18?,19-/m1/s1
InChI key	FIHJKUPKCHIPAT-JQXDXKTESA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332
预防措施声明	P261 - P280 - P301 + P312 + P330
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

325208

Fluorochem

Artesunate

95%

264元/1g; 682元/5g; 1232元/10g; 1980元/25g;

展开

基本信息

CAS Number	88495-63-0
MDL Number	MFCD00866204

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H312: Harmful in contact with skin. H332: Harmful if inhaled.
防范说明	P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific measures (see . on this label). P330: Rinse mouth. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to local regulations.