| CAS: | 88247-69-2 | |
| 分子式: | C27H40D6O2 | |
| 分子量: | 408.7 | |
| 英文名称: |
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| 用途: | 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types. |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||
| C911582 | MACKLIN | 25-hydroxy Cholesterol-d6 | 98% | 2221元/1mg; | 展开 | ||||||||||||||||||||||||||
储存：-20°C，密闭，干燥 | |||||||||||||||||||||||||||||||
| 700053P | Avanti | 25-hydroxycholesterol-d6 | Avanti Polar Lipids | 3340.77元/1 mg; | 展开 | ||||||||||||||||||||||||||
产品说明 一般描述 25-hydroxycholesterol (25HC) is synthesized from cholesterol in the presence of oxygen and enzyme cholesterol 25-hydroxylase and the conversion is dependent on nicotinamide adenine dinucleotide phosphate (NADPH) during toll-like receptor activation. 25HC is catabolized to 7α-hydroxylated sterol. 25-hydroxycholesterol-d6 is the deuterated form of 25-hydroxycholesterol. 应用 25-hydroxycholesterol-d6 has been used as an internal standard:
生化/生理作用 25-hydroxycholesterol is a liver X receptor ligand. This bioactive lipid regulates immune response and macrophages production from monocytes. 25-HC serves as an antiviral effector and may have therapeutic potential. It reduces cholesterol biosynthesis by inactivating sterol regulatory element binding protein and inhibits HMG-CoA reductase (HMGCR). 25-HC may play a protective role in myocardial ischemia-reperfusion injury by inhibiting apoptosis and regulating mitogen-activated protein kinase (MAPK) pathway. 包装 5 mL Amber Glass Screw Cap Vial (700053P-1mg) 基本信息
产品性质
安全信息
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