CAS 88191-84-8; mdl 28170

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货号

品牌

产品名称

规格

包装、参考价格

M876800

MACKLIN

MDL-28170

≥99%

270元/5mg; 515元/10mg;

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储存：2-8℃

M6690

Sigma-Aldrich

MDL 28170

≥90% (TLC)

3056.06元/25 MG;

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产品说明

Amino Acid Sequence

Z-Val-Phe-al

应用

MDL 28170已被用作钙蛋白酶抑制剂：

在大鼠心脏骤停模型中研究对神经炎症和坏死的影响
分析对牛肉半膜肌神经元一氧化氮合酶(nNOS)降解的影响
研究对大鼠脑损伤的保护作用及骨髓间充质干细胞在大鼠脑内的存活率

生化/生理作用

MDL 28170 是一种有效的细胞渗透性钙蛋白酶 I 和 II 抑制剂；减少培养的背根神经节神经元中辣椒素介导的细胞死亡。减少 H₂O₂ 和 A23187 处理的 PC12 细胞凋亡的发生。γ-分泌酶抑制剂。
MDL 28170对大鼠脊髓损伤、局灶性脑缺血和新生儿缺氧缺血均有神经保护作用。它还有抗炎和抗神经退化特性。MDL 28170可穿过血脑屏障，并轻松穿透细胞膜。

基本信息

经验(实验)分子式	C₂₂H₂₆N₂O₄
分子量	382.45
MDL编号	MFCD00798796
PubChem化学物质编号	24278565
NACRES	NA.77

产品性质

质量水平	200
测定	≥90% (TLC)
组成	Peptide Content, >90%
溶解性	DMSO: 26 mg/mL H₂O: insoluble methanol: soluble
运输	wet ice
储存温度	2-8℃
SMILES string	[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C
InChI	1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1
InChI key	NGBKFLTYGSREKK-ANYOKISRSA-N
Gene Information	human ... CAPN1(823), CAPN2(824)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

208722

Sigma-Aldrich

Calpain Inhibitor III-CAS 88191-84-8-Calbiochem

The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

2741.8元/25 MG;

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产品说明

一般描述

A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.

包装

25 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
calpain 1, calpain 2
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Z-Val-Phe-CHO

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Chatterjee, S., et al. 1998. J. Med. Chem.41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₂H₂₆N₂O₄
分子量	382.45
MDL编号	MFCD00798796
NACRES	NA.77

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized solid
效能	8 nM IC₅₀
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	DMSO: 20 mg/mL (Use only anhydrous DMSO.)
运输	ambient
储存温度	2-8℃
InChI	1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1
InChI key	NGBKFLTYGSREKK-PMACEKPBSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable