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CAS: 875787-07-8
分子式: C21H12ClF5N2
分子量: 422.78
英文名称: 
way-252623
2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)indazole
cid 16734800
lxr-623
2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2h-indazole
lxr623
用途: LXR-623是一种新型的liver X-receptor(LXR)激动剂,对LXR-α和LXR-β的IC50值分别为179 nM和24 nM。它具有生物口服活性并能通过血脑屏障。
推荐供应商
货号品牌产品名称规格包装、参考价格
L872559MACKLINLXR-62399%315元/5mg;   435元/10mg;   1499元/50mg;   2418元/100mg;   咨询
储存:-20℃
状态:白色到米黄色粉末
L792316MACKLINLXR-62310mM in DMSO648元/1ml;   咨询
储存:-20°C
L0344TCILXR-623>97.0%(GC)890元/10MG;   2990元/50MG;   咨询

基本信息

纯度/分析方法>97.0%(GC)
分子式/分子量C21H12ClF5N2 = 422.78
外观与形状(20℃)固体
储存温度0-10℃
应避免的情况加热
Reaxys-RN19574625
MDL编号MFCD16495812

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(GC)min. 97.0 %
Melting point98.0 to 102.0 ℃

物性(参考值)

熔点100 ℃
PZ0257Sigma-AldrichWAY-252623≥98% (HPLC)1117.23元/5 MG;   4498.97元/25 MG;   咨询

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

WAY-252623 (LXR623) is an orally available, potent and highly selective Liver X receptors (LXRs) agonist that significantly reduced total and LDL-cholesterol. WAY-252623 reduces lesion progression in the murine LDLR(-/-) atherosclerosis model.

其他说明

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式C21H12ClF5N2
分子量422.78

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
manufacturer/tradenamePfizer®
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
创始人Pfizer
储存温度room temp

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P301 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
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