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CAS: 87333-19-5
分子式: C23H32N2O5
分子量: 416.50
中文名称: 
雷米普利
(S)-2-[N-(1-乙氧羰基-3-苯基-丙基)丙氨酰基]-2-氮杂二环[3.3.0]辛烷-3-羧酸
英文名称: 
cyclopenta(b)pyrrole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-p
(2S-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl) amino)-1-oxopropyl
hoe 498
ramipril
(2S,3as,6as)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
性质描述: 白色或类白色结晶性粉末。熔点107.0-110.0℃。
用途: 降血压药，用于高血压、充血性心力衰竭。
推荐供应商
货号品牌产品名称规格包装、参考价格
R797919MACKLIN雷米普利10mM in DMSO259元/1ml;   咨询
储存：-20°C
R0219TCIRamipril>98.0%(T)(HPLC)290元/1G;   990元/5G;   咨询

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C23H32N2O5 = 416.52
外观与形状(20℃)固体
储存温度0-10℃
应避免的情况加热
包装和容器 1G-带有塑料内管的玻璃瓶 (查看图片)
Reaxys-RN4214464
Merck Index (14)8103
MDL编号MFCD00865775

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Neutralization titration)min. 98.0 %
Melting point107.0 to 111.0 ℃
Specific rotation [a]20/D+38.0 to +42.0 deg(C=1, 0.1N HCl in EtOH)

物性(参考值)

熔点109 ℃
比旋光度 [α]D40° (C=1,0.1 NHCl in EtOH)
溶解性(可溶于)甲醇

安全信息

图形或危害标志
信号词危险
危险性说明H360 : 可能对生育能力或胎儿造成伤害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑：求医/就诊。
P405 : 存放处须加锁。

相关法规

RTECS#GY5879600
PHR1446SupelcoRamiprilPharmaceutical Secondary Standard; Certified Reference Material1003.39元/1 G;   咨询

产品说明

一般描述

Ramipril is an angiotensin-converting-enzyme (ACE) inhibitor, which acts on the renin angiotensin aldosterone system. It is widely used in reducing hypertension by the suppression of the effects of angiotensin II at its receptor, thereby blocking the renin-angiotensin system.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Ramipril may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and high-performance liquid chromatography technique.

生化/生理作用

Angiotensin converting enzyme (ACE) inhibitor.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3757 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C23H32N2O5
分子量416.51
MDL编号MFCD00865775
PubChem化学物质编号329822606
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 1 g
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to BP 751
traceable to PhEur R0145000
traceable to USP 1598303
储存温度2-8℃
SMILES stringO=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3
InChI1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
InChI keyHDACQVRGBOVJII-JBDAPHQKSA-N
Gene Informationhuman ... ACE(1636)

安全信息

象形图GHS08
警示用语：Danger
危险声明H360FD
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
R0145000RamiprilEuropean Pharmacopoeia (EP) Reference Standard1259.15元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Angiotensin converting enzyme (ACE) inhibitor.

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C23H32N2O5
分子量416.51
MDL编号MFCD00865775
PubChem化学物质编号329823973
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringO=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3
InChI1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
InChI keyHDACQVRGBOVJII-JBDAPHQKSA-N
Gene Informationhuman ... ACE(1636)

安全信息

象形图GHS08
警示用语：Danger
危险声明H360FD
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
R0404Sigma-AldrichRamipril≥98% (HPLC)2765.78元/100 MG;   4406.45元/250 MG;   咨询

产品说明

包装

100, 250 mg in poly bottle

生化/生理作用

Angiotensin converting enzyme (ACE) inhibitor.

特点和优势

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R0404.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

基本信息

经验(实验)分子式C23H32N2O5
分子量416.51
MDL编号MFCD00865775
PubChem化学物质编号24724586

产品性质

生物来源synthetic (organic)
质量水平100
测定≥98% (HPLC)
形式powder
颜色 white
溶解性DMSO: ~18 mg/mL
创始人Sanofi Aventis
储存温度2-8℃
SMILES stringO=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3
InChI1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
InChI keyHDACQVRGBOVJII-JBDAPHQKSA-N
Gene Informationhuman ... ACE(1636)

安全信息

象形图GHS08
警示用语：Danger
危险声明H360FD
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
BP751RamiprilBritish Pharmacopoeia (BP) Reference Standard2322.51元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Angiotensin converting enzyme (ACE) inhibitor.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C23H32N2O5
分子量416.51
MDL编号MFCD00865775
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringO=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3
InChI1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
InChI keyHDACQVRGBOVJII-JBDAPHQKSA-N
Gene Informationhuman ... ACE(1636)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
1598303USPRamiprilUnited States Pharmacopeia (USP) Reference Standard3231.47元/125 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Angiotensin converting enzyme (ACE) inhibitor.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C23H32N2O5
分子量416.51
MDL编号MFCD00865775
PubChem化学物质编号329751020
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringO=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3
InChI1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
InChI keyHDACQVRGBOVJII-JBDAPHQKSA-N
Gene Informationhuman ... ACE(1636)

安全信息

象形图GHS08
警示用语：Danger
危险声明H360FD
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
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