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CAS: 871307-18-5
分子式: C21H14ClFN6
分子量: 404.8
英文名称: 
tpl2 kinase inhibitor-cas 871307-18-5-calbiochem
4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
用途: Tpl2 kinase inhibitor is a reversible inhibitor of tumor progression locus 2
推荐供应商
货号品牌产品名称规格包装、参考价格详情
T912898MACKLINTpl2 Kinase Inhibitor98%3271元/1mg;   展开
储存:-20°C,密闭,干燥
616373Sigma-AldrichTpl2 Kinase Inhibitor-CAS 871307-18-5-CalbiochemThe Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphory2741.8元/1 MG;   展开

产品说明

一般描述

A cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM). Displays significant selectivity over other related kinases (IC50 = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC50 = 700 nM and 8.5 µM, respectively).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC50: 50 nM against Tpl2 kinase
Primary Target
Tpl2 Kinase
Product competes with ATP.
Reversible: yes

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5288.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C21H14ClFN6
分子量404.83

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性DMSO: 10 mg/mL
运输ambient
储存温度−20℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 2
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