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CAS: 870-50-8
分子式: C10H18N2O4
分子量: 230.26
熔点: 89-92℃
中文名称: 
二叔丁基偶氮二异丁腈
英文名称: 
Azodicarboxylic acid di-tert-butyl ester
di-tert-butyl azodicarboxylate
推荐供应商
货号品牌产品名称规格包装、参考价格
D806959MACKLIN偶氮二甲酸二叔丁酯98%28元/5g;   51元/25g;   160元/100g;   675元/500g;   3200元/2.5kg;   咨询
储存：2~8°C,避光
状态：黄色晶体,粉末或结晶粉末
126274J&KDi-tert-butyl azodicarboxylate98%257元/5G;   954元/25G;   咨询

基本信息

分子式C10H18N2O4
分子量230.26
熔点89-92
MDL编码MFCD00015001
Beilstein1911434
EINECS 编号212-796-9
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
TSCA否
L00294Alfa AesarDi-tert-butyl azodicarboxylate98%400元/5g;   1749元/25g;   咨询

应用
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates. It is also used in the electrophilic amination of beta-keto esters catalyzed by an axially chiral guanidine. It serves as a precursor in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such as L-proline or (S)-2-pyrrolidinyl tetrazole. It is also utilized in the asymmetric Friedel-Crafts amination through a chiral organocatalyst. Further, it acts as a reactant for preparation of hexapeptide key fragments through stereo selective selenocyclization/oxidative deselenylation reactions. In addition to this, it is employed as a starting material in the synthesis of pyrroloisoquinoline template through stereoselective N-acyliminium-mediated cyclization and enolate amination for preparation of peptidomimetic compounds and Barbier-type propargylation reactions.

备注
Light sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong bases and alcohols.

基本信息

MDL
MFCD00015001

EINECS
212-796-9

分子式
(CH3)3CO2C-N=N-CO2C(CH3)3

分子量
230.27

熔点
89-92°

灵敏度
Light Sensitive. Ambient temperatures.

溶解性
Soluble in most organic solvents. Insoluble in water.

Beilstein
1911434

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
4.1

包装组
III

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

TSCA
否

C36692Alfa AesarDi-tert-butyl azodicarboxylate97%525元/5g;   1786元/25g;   6205元/100g;   咨询

基本信息

Ref#
36692

MDL
15001

分子式
C10 H18 N2 O4

分子量
230.26

安全信息

危险等级
4.1

包装组
III

135992Sigma-AldrichDi-tert-butyl azodicarboxylate98%249.32元/5 G;   651.93元/25 G;   咨询

产品说明

一般描述

我们致力于为您提供更环保的替代产品，以符合“绿色化学的12项原则”的一项或多项原则要求。该产品具有增强催化作用。

应用

在有氧条件下，铜催化的醇类绿色氧化的共氧化剂。

在常压，室温条件下，改性 Markó 使用空气或分子氧将醇类有氧氧化
反应物用于：

  • 通过立体选择性硒环化/氧化脱硒化或肼化/环化反应制备六肽关键片段
  • 不对称迈克尔加成反应
  • 通过光延反应(Mitsunobu 反应)制备二肽基肽酶 IV 依赖性水溶性前药
  • 通过立体选择性 N-酰基亚胺介导的环化和烯醇化胺化合成吡咯并喹啉模板，用于合成拟肽化合物
  • 巴比尔型炔丙基化反应
  • 合成细菌肽脱甲酰基酶(PDF)抑制剂 fumimycin
  • 甘氨酸席夫碱的不对称胺化

通过手性有机催化剂进行不对称 Friedel-Crafts 胺化反应。
通过轴向手性胍催化 ß-酮酯的亲电胺化试剂。采用L-脯氨酸或(S)-2-吡咯烷基四唑等有机催化剂进行 3,6-二氢吡咯烷嘧啶对映选择性合成的构建块。

包装

5, 25 g in glass bottle

基本信息

线性分子式(CH3)3COCON=NCOOC(CH3)3
分子量230.26
Beilstein1911434
EC 号212-796-9
MDL编号MFCD00015001
PubChem化学物质编号24848251
NACRESNA.22

产品性质

质量水平200
测定98%
环保替代产品特性Catalysis
Learn more about the Principles of Green Chemistry.
mp89-92 ℃ (lit.)
环保替代产品分类Aligned
储存温度2-8℃
SMILES stringCC(C)(C)OC(=O)\N=N\C(=O)OC(C)(C)C
InChI1S/C10H18N2O4/c1-9(2,3)15-7(13)11-12-8(14)16-10(4,5)6/h1-6H3/b12-11+
InChI keyQKSQWQOAUQFORH-VAWYXSNFSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
11625Sigma-AldrichDi-tert-butyl azodicarboxylatepurum, ≥98.0% (GC)278.16元/5 G;   703.21元/25 G;   咨询

产品说明

一般描述

Di-tert-butyl azodicarboxylate is a an acid labile reagent for Mitsunobu reactions allowing facile isolation of products and for the electrophilic amination and hydrazination of enolates and lithium alkyls.

应用

反应物用于：

  • 通过立体选择性硒环化/氧化脱硒化或肼化/环化反应制备六肽关键片段
  • 不对称迈克尔加成反应
  • 通过光延反应(Mitsunobu 反应)制备二肽基肽酶 IV 依赖性水溶性前药
  • 通过立体选择性 N-酰基亚胺介导的环化和烯醇化胺化合成吡咯并喹啉模板，用于合成拟肽化合物
  • 巴比尔型炔丙基化反应
  • 合成细菌肽脱甲酰基酶(PDF)抑制剂 fumimycin
  • 甘氨酸席夫碱的不对称胺化

基本信息

线性分子式(CH3)3COCON=NCOOC(CH3)3
分子量230.26
Beilstein1911434
EC 号212-796-9
MDL编号MFCD00015001
PubChem化学物质编号329749512
NACRESNA.22

产品性质

质量水平200
等级purum
测定≥98.0% (GC)
mp89-92 ℃ (lit.)
89-92 ℃
储存温度2-8℃
SMILES stringCC(C)(C)OC(=O)\N=N\C(=O)OC(C)(C)C
InChI1S/C10H18N2O4/c1-9(2,3)15-7(13)11-12-8(14)16-10(4,5)6/h1-6H3/b12-11+
InChI keyQKSQWQOAUQFORH-VAWYXSNFSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
991803AmethystDi-tert-butyl azodicarboxylate98%, 用于合成68元/5G;   176元/25G;   542元/100G;   咨询

基本信息

分子式C10H18N2O4
分子量230.26
熔点89-92
MDL编码MFCD00015001
Beilstein1911434
EINECS 编号212-796-9
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
TSCA否
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