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CAS: 866893-90-5
分子式: C20H28N6O
分子量: 368.48
中文名称: 
amyloid-β forty-two inducer 4
英文名称: 
aftin-4
(2R)-2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9h-purin-2-yl]amino]-1-butanol
n6-methyl-(R)-roscovitine
推荐供应商
货号品牌产品名称规格包装、参考价格
A897399MACKLIN(R)-2-((6-(苄基(甲基)氨基)-9-异丙基-9H-嘌呤-2-基)氨基)丁醇97%1144元/25mg;   3311元/100mg;   5626元/250mg;   咨询
储存:-20°C,避光保存于惰性气体中
SML1578Sigma-AldrichAftin-4≥98% (HPLC)2255.27元/5 MG;   6765.81元/25 MG;   咨询

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

基本信息

经验(实验)分子式C20H28N6O
分子量368.48

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件protect from light
颜色 white to beige
溶解性DMSO: 25 mg/mL, clear
储存温度−20℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
CAS号首数字顺序排列: 1 2 3 4 5 6 7 8 9