CAS 86541-74-4; 1h-1-benzazepine-1-acetic acid, 2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe

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货号

品牌

产品名称

规格

包装、参考价格

B887820

MACKLIN

盐酸贝那普利

≥ 98 % HPLC

75元/1g; 285元/5g; 1335元/25g;

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储存：室温
状态：白色到灰白色粉末

B3611

TCI

Benazepril Hydrochloride

>98.0%(T)(HPLC)

290元/1G; 990元/5G;

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基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₂₄H₂₈N₂O₅・HCl = 460.96
外观与形状(20℃)	固体
相关CAS RN	86541-75-5
Reaxys-RN	4286047
PubChem物质ID	125307624
SDBS (AIST Spectral DB)	52817
Merck Index (14)	1031
MDL编号	MFCD00895734

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Specific rotation [a]20/D	-134.0 to -140.0 deg(C=1, EtOH)

物性(参考值)

熔点	183 ℃
比旋光度 [α]D	-137° (C=1,EtOH)
溶解性(可溶于)	甲醇

相关法规

RTECS#

CX7065000

127998

J&K

Benazepril Hydrochloride

98.5%, 一种长效的血管紧张素转换酶 (ACE) 抑制剂

941元/1G; 3278元/5G;

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基本信息

分子式	C₂₄H₂₈N₂O₅·HCl
分子量	460.95
熔点	183
MDL编码	MFCD00895734
Beilstein	4286047
Merck	14,1031
EINECS 编号	213-628-7
存储条件	Freezer -20℃

产品描述

Benazepril HCl是一种用于治疗高血压的药物。

靶点（IC50 & Targe）

ACE

体外研究

在自发性高血压大鼠（SHR）中，Benazepril hydrochloride（3或10 mg/kg/天，口服14天）剂量依赖性地抑制去甲肾上腺素（NE）连续输注所引起的血压增加，并且抑制单胺氧化酶抑制剂tranylcypromine诱导的癫痫。[1] 在正常血压大鼠中，Benazepril hydrochloride（30 毫克/千克，口服）减小甘油三酯和总胆固醇水平。在胆固醇喂养的兔子中，Benazepril hydrochloride（3 毫克/千克，皮下注射）导致主动脉粥样硬化显著减少，而不会降低高胆固醇血症。在正常血压大鼠中，Benazepril hydrochloride（100 毫克/千克，口服）对尿量和尿中电解质排泄量没有影响，但会降低PSP排泄。在DOCA/盐自发性高血压大鼠中，Benazepril hydrochloride（10 毫克/千克，口服）抑制尿蛋白排泄的增加。[3] 在实验诱导或自发产生的慢性肾功能衰竭的猫中，Benazepril hydrochloride给药校正系统性高血压并显著降低血管紧张素II和醛甾酮。在实验诱导或自发产生的慢性肾功能衰竭的猫中，Benazepril hydrochloride降低了血清肌酸酐和尿蛋白浓度。[4] 在性肾功能衰竭犬残肾模型中，Benazepril hydrochloride显著降低血压，血管紧张素II和醛甾酮并增大施用中断到服药前水平。[5]

参考文献

[1] Yamamoto S, et al. Arzneimittelforschung,?991, 41(6), 602-607.

[2] Yamamoto S, et al. Arzneimittelforschung,?991, 41(9), 913-923.

[3] Watanabe T, et al. J Vet Med Sci,?007, 69(10), 1015-1023.

[4] Mishina M, et al. J Vet Med Sci,?008, 70(5), 455-460.

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H410
防范说明	P264 P270 P273 P301+P312 P330 P391 P501
UN号码	3077
危险分类	9
包装等级	III
WGK	2
RTECS	CX7065000

Y0001025

Benazepril Hydrochloride

European Pharmacopoeia (EP) Reference Standard

1572.27元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

贝那普利是一种长效的血管紧张素转换酶 (ACE) 抑制剂。

包装

Unit quantity: 170 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₄H₂₈N₂O₅ · HCl
分子量	460.95
MDL编号	MFCD00895734
PubChem化学物质编号	329831225
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O
InChI	1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1
InChI key	VPSRQEHTHIMDQM-FKLPMGAJSA-N
Gene Information	human ... ACE(1636)

安全信息

象形图
警示用语：	Warning
危险声明	H361fd
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0001038

Benazepril for system suitability

European Pharmacopoeia (EP) Reference Standard

1572.27元/ ;

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产品说明

一般描述

生化/生理作用

贝那普利是一种长效的血管紧张素转换酶 (ACE) 抑制剂。

包装

Unit quantity: 0.016 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₄H₂₈N₂O₅ · HCl
分子量	460.95
MDL编号	MFCD00895734
PubChem化学物质编号	329831233
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O
InChI	1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1
InChI key	VPSRQEHTHIMDQM-FKLPMGAJSA-N
Gene Information	human ... ACE(1636)

安全信息

象形图
警示用语：	Warning
危险声明	H361fd
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

B0935

Sigma-Aldrich

Benazepril Hydrochloride

≥98% (HPLC), solid

7725.74元/250 MG; 13531.6元/500 MG;

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产品说明

包装

250, 500 mg in glass bottle

生化/生理作用

贝那普利是一种长效的血管紧张素转换酶 (ACE) 抑制剂。

特点和优势

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₂₄H₂₈N₂O₅ · HCl
分子量	460.95
MDL编号	MFCD00895734
PubChem化学物质编号	24724409
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
溶解性	H₂O: >5 mg/mL
创始人	Novartis
SMILES string	Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O
InChI	1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1
InChI key	VPSRQEHTHIMDQM-FKLPMGAJSA-N
Gene Information	human ... ACE(1636)

安全信息

象形图
警示用语：	Warning
危险声明	H361fd
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

PHR1912

Supelco

Benazepril Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

2252.27元/250 MG;

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产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

贝那普利是一种长效的血管紧张素转换酶 (ACE) 抑制剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB0978 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₂₄H₂₈N₂O₅ · HCl
分子量	460.95
MDL编号	MFCD00895734
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
形式	powder
CofA	current certificate can be downloaded
包装	pkg of 250 mg
application(s)	pharmaceutical
药典可追溯性	traceable to PhEur Y0001025 traceable to USP 1048619
储存温度	2-8℃
SMILES string	Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O
InChI	1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1
InChI key	VPSRQEHTHIMDQM-FKLPMGAJSA-N
Gene Information	human ... ACE(1636)

安全信息

象形图
警示用语：	Warning
危险声明	H361fd
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

1048619

USP

Benazepril Hydrochloride

United States Pharmacopeia (USP) Reference Standard

3231.47元/125 MG;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

贝那普利是一种长效的血管紧张素转换酶 (ACE) 抑制剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₄H₂₈N₂O₅ · HCl
分子量	460.95
MDL编号	MFCD00895734
PubChem化学物质编号	329749101
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O
InChI	1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1
InChI key	VPSRQEHTHIMDQM-FKLPMGAJSA-N
Gene Information	human ... ACE(1636)

安全信息

象形图
警示用语：	Warning
危险声明	H361fd
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable