CAS 86390-77-4; 1-oleoyl-2-acetylglycerol

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货号

品牌

产品名称

规格

包装、参考价格

O911530

MACKLIN

1-油酰基-2-乙酰基-sn-丙三醇

50 mg/mL in Acetonitrile

998元/5mg;

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储存：-20°C，密闭，干燥
状态：无色到微黄色液体

495414

Sigma-Aldrich

1-Oleoyl-2-acetyl-sn-glycerol-CAS 86390-77-4-Calbiochem

Cell-permeable diacylglycerol analog that activates Ca²⁺-dependent protein kinase C.

1263.18元/5 MG; 2625.36元/1 SET; 3848.96元/25 MG;

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产品说明

一般描述

Note: 1 set = 10 x 500 µg.
Cell-permeable diacylglycerol analog that activates Ca²⁺-dependent protein kinase C. Also a stimulator of secretion and aggregation in blood platelets.

包装

5, 25 mg in Plastic ampoule
1 set in Glass bottle

生化/生理作用

Cell permeable: yes
Primary Target
Ca2+-dependent protein kinase C
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Unstable in solution; reconstitute just prior to use. The material can be dissolved in chloroform, aliquoted, dried under a stream of nitrogen, and stored at -20°C.

其他说明

Florin-Christensen, J. 1993. Biochem. J.289, 783.
Benz, I., et al. 1992. J. Membr. Biol. 130, 183.
Haeffner, E.W., and Wittmann, U. 1992. J. Lipid Mediat.5, 237.
Gilmore, T., and Martin, G.S. 1983. Nature306, 487.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₃H₄₂O₅
分子量	398.58
MDL编号	MFCD00166985

产品性质

质量水平	100
测定	≥95% (TLC)
形式	oil
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
溶解性	DMSO: soluble ethanol: soluble
格式	neat
运输	ambient
储存温度	−20℃
InChI	1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10-/t22-/m0/s1
InChI key	PWTCCMJTPHCGMS-YRBAHSOBSA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

O6754

Sigma-Aldrich

1-Oleoyl-2-acetyl-sn-glycerol

≥97% (TLC), oil

2180.56元/5 MG; 3490.2元/10 MG; 7590.32元/25 MG;

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产品说明

包装

5, 10, 25 mg in ampule

生化/生理作用

1-油酰-2-乙酰基- 锡 -甘油是一种合成的、细胞渗透性的甘油二酯类似物。常作为钙依赖性蛋白激酶 C (PKC) 的激活剂。

注意

储存中或成溶液时可能发生异构化。

基本信息

经验(实验)分子式	C₂₃H₄₂O₅
分子量	398.58
Beilstein	8168731
MDL编号	MFCD00166985
PubChem化学物质编号	24898039
NACRES	NA.25

产品性质

质量水平	200
生物来源	synthetic (organic)
测定	≥97% (TLC)
形式	oil
溶解性	ethanol: 20 mg/mL (lit.)(lit.) DMSO: soluble (lit.)(lit.)
官能团	ketone
运输	dry ice
储存温度	−20℃
SMILES string	CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](CO)OC(C)=O
InChI	1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10-/t22-/m0/s1
InChI key	PWTCCMJTPHCGMS-YRBAHSOBSA-N
Gene Information	human ... PRKCA(5578)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves

800100O

Avanti

18:1-2:0 DG

1-oleoyl-2-acetyl-sn-glycerol, neat oil

1124.64元/10 MG; 1997.9元/25 MG;

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产品说明

一般描述

18:1-2:0 DG, also called 1-oleoyl-2-acetyl-sn-glycerol (OADG), is a membrane permeable and synthetic analog of diacyl glycerol (DAG).

应用

18:1-2:0 DG (1-oleoyl-2-acetyl-sn-glycerol) may be used:

in the induction of superoxide generation in neutrophils
as a substrate for platelet-activating factor acetyl hydrolases
as a protein kinase C (PKC) activator in adrenal glands

生化/生理作用

18:1-2:0 DG (OAG) halts the inhibition of glucose uptake by the phospholipase C (PLC) inhibitor, U73122. It also inhibits mitochondrial permeability transition pore (MPTP) formation and prevents fatty acid release and necrosis in lung fibroblasts. OAG is a protein kinase C (PKC) activator. It also inhibits TWIK-related acid-sensitive (TASK)-like potassium channels in peripheral arterial chemoreceptors. OAG stimulates 5-lipooxygenase (5-LO) in human polymorphonuclear leukocytes (PMNL).

包装

5 mL PTFE Vial with Screw Cap (800100O-25mg)
5 mL PTFE Vial with Screw Cap (800100O-10mg)

储存及稳定性

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20℃. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

其他说明

Effective concentration: Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.
Delivery to cells: Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

基本信息

经验(实验)分子式	C₂₃H₄₂O₅
分子量	398.58

产品性质

测定	>99% (TLC)
包装	pkg of 1 × 10 mg (with screw cap (800100O-10mg)) pkg of 1 × 25 mg (with screw cap (800100O-25mg))
manufacturer/tradename	Avanti Polar Lipids 800100O
运输	dry ice
储存温度	−20℃
InChI	1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10-/t22-/m0/s1
InChI key	PWTCCMJTPHCGMS-YRBAHSOBSA-N

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable