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CAS: 86386-73-4
分子式: C13H12F2N60
分子量: 306.270
中文名称: 
氟康唑
2-(2,4-二氟苯基)-1,3-双(1H-1,2,4-三唑-1-基)-2-丙醇
英文名称: 
Triflucan
1h-1,2,4-triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1h-1,2,4-triazol
-1-ylmethyl)-
2-(2,4-difluorophenyl)-1,3-bis(1h-1,2,4-triazol-1-yl)-2-propanol
alpha-(2,4-difluorophenyl)-alpha-(1h-1,2,4-triazol-1-ylmethyl)-1h-1,2,4- tria
zole-1-ethanol
diflucan
fluconazole
uk 49858
性质描述: 熔点138-140℃。
用途: 美国辉瑞公司上市的新一代抗真菌药物,对白色含球与隐球菌具有较高的抗菌活性。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
F793680MACKLIN氟康唑10mM in DMSO261元/1ml;   展开
储存:-20°C
状态:液体
F0677TCIFluconazole>98.0%(GC)(T)300元/1G;   865元/5G;   展开

基本信息

纯度/分析方法>98.0%(GC)(T)
分子式/分子量C13H12F2N6O = 306.28
外观与形状(20℃)固体
Reaxys-RN4269710
PubChem物质ID87560996
Merck Index (14)4122

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(GC)min. 98.0 %
Purity(Nonaqueous Titration)min. 98.0 %
Melting point138.0 to 142.0 ℃

物性(参考值)

熔点141 ℃
溶解性(可溶于)甲醇

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#XZ4810000
433638J&KFluconazole98.5%66元/250MG;   98元/1g;   展开

基本信息

分子式C13H12F2N6O
分子量306.28
熔点138-142
MDL编码MFCD00274549
Beilstein4269710
Merck14,4122

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
H335
防范说明P261
P305+P351+P338
RTECSXZ4810000
F-097SupelcoFluconazole solution10 mg/mL in ethanol, certified reference material, ampule of 1 mL, Cerilliant®3931.89元/1 ML;   展开

产品说明

一般描述

Fluconazole, sold under trade names such as Trican, Monicure, Diflucan®, and Afungil, is an antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. This Certified Spiking Solution® is suitable as starting material for calibrators, controls, or linearity standards for therapeutic drug monitoring or clinical and diagnostic testing of fluconazole in patient blood, serum, or plasma samples by HPLC or LC-MS/MS.

法律信息

CERILLIANT is a registered trademark of Cerilliant Corporation
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Diflucan is a registered trademark of Pfizer, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Cerilliant Corporation

基本信息

经验(实验)分子式C13H12F2N6O
分子量306.27
MDL编号MFCD00274549

产品性质

质量水平300
等级certified reference material
特点 Snap-N-Spike®/Snap-N-Shoot®
包装ampule of 1 mL
manufacturer/tradenameCerilliant®
浓度10 mg/mL in ethanol
格式single component solution
储存温度−20℃
InChI1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI keyRFHAOTPXVQNOHP-UHFFFAOYSA-N

安全信息

象形图GHS02GHS07GHS08
警示用语:Danger
危险声明H225 - H319 - H360D
预防措施声明P201 - P202 - P210 - P233 - P305 + P351 + P338 - P308 + P313
危险分类Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B
储存分类代码3 - Flammable liquids
WGKWGK 2
闪点(F)55.4 °F
闪点(C)13 ℃
Y0000558Fluconazole for peak identificationEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C13H12F2N6O
分子量306.27
MDL编号MFCD00274549
PubChem化学物质编号329831020
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringFC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
InChI1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI keyRFHAOTPXVQNOHP-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H360D - H412
预防措施声明P201 - P202 - P264 - P273 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
F8929Sigma-AldrichFluconazole≥98% (HPLC), powder2636.35元/100 MG;   展开

产品说明

一般描述

氟康唑用于治疗中性细胞减少症成人患者的侵袭性假丝酵母菌病(IC)。

应用

氟康唑已用于评估最低抑菌浓度(MIC)-真菌检测。它还被用作植物抗真菌检测的阳性对照。

包装

100 mg in glass bottle

生化/生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

特点和优势

该化合物由 Pfizer开发。想浏览其他制药公司开发的化合物和已批准药物/候选药物目录, 请单击此处。
该化合物是ADME Tox研究的特色产品。点击此处 了解更多ADME Tox的特色产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问sigma.com/discover-bsm。

其他说明

Scripps Center for Metabolomics(斯克里普斯代谢组学中心)独立生成的串联质谱数据,可以PDF格式查看或下载。F8929.pdf 经过测试的代谢物在Scripps Center for Metabolomics(斯克里普斯代谢组学中心) METLIN代谢物数据库有重点介绍。更多信息请见sigma.com/metlin。

基本信息

经验(实验)分子式C13H12F2N6O
分子量306.27
MDL编号MFCD00274549
PubChem化学物质编号24724485
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
溶解性DMSO: 5 mg/mL
作用机制enzyme | inhibits
抗生素抗菌谱fungi
创始人Pfizer
储存温度room temp
SMILES stringFC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
InChI1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI keyRFHAOTPXVQNOHP-UHFFFAOYSA-N
Gene Informationhuman ... CYP1A2(1544)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H360D - H412
预防措施声明P201 - P202 - P264 - P273 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
PHR1160SupelcoFluconazolePharmaceutical Secondary Standard; Certified Reference Material1359.83元/1 G;   展开

产品说明

一般描述

用于质量控制的制药二级标准品,可为制药实验室和制造商提供了一种方便且经济的替代方案,用于内部工作标准品的制备。
氟康唑是一种广谱抗菌药物。用于口腔、食管、阴道念珠菌病及其他严重的系统性念珠菌感染的修复。该药对新型隐球菌引起的脑膜炎也有效。

应用

氟康唑可用作药物参考标准品,通过色谱分析和分光光度测定技术对制药配方中的分析物进行测定。
这些二级标准品是经过检验的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他标定应用。

生化/生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

分析说明

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他说明

分析物的数值在批次间变化很大。
该认证标准物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

要查看该材料的分析证书示例,请在下面的栏位中输入LRAC0255。这只是一个示例证书,可能不是您收到的批次。

基本信息

经验(实验)分子式C13H12F2N6O
分子量306.27
MDL编号MFCD00274549
PubChem化学物质编号329823177
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to BP 1174
traceable to PhEur Y0000557
traceable to USP 1271700
储存温度2-30℃
SMILES stringFC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
InChI1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI keyRFHAOTPXVQNOHP-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H360D - H412
预防措施声明P201 - P202 - P264 - P273 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0000557FluconazoleEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C13H12F2N6O
分子量306.27
MDL编号MFCD00274549
PubChem化学物质编号329831019
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringFC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
InChI1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI keyRFHAOTPXVQNOHP-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H360D - H412
预防措施声明P201 - P202 - P264 - P273 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1271700USPFluconazoleUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C13H12F2N6O
分子量306.27
MDL编号MFCD00274549
PubChem化学物质编号329749851
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringFC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
InChI1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI keyRFHAOTPXVQNOHP-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H360D - H412
预防措施声明P201 - P202 - P264 - P273 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP1174FluconazoleBritish Pharmacopoeia (BP) Reference Standard2144.18元/100 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C13H12F2N6O
分子量306.27
MDL编号MFCD00274549
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringFC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
InChI1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI keyRFHAOTPXVQNOHP-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H360D - H412
预防措施声明P201 - P202 - P264 - P273 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP1175Fluconazole impurity standardBritish Pharmacopoeia (BP) Reference Standard1989元/50 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C13H12F2N6O
分子量306.27
MDL编号MFCD00274549

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式mixture
储存温度2-8℃
SMILES stringFC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
InChI1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI keyRFHAOTPXVQNOHP-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H360D - H412
预防措施声明P201 - P202 - P264 - P273 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
036566Fluorochem2,4-Difluoro-alpha,alpha-1-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol97%1584元/25g;   3960元/100g;   13860元/500g;   展开

基本信息

CAS Number86386-73-4
MDL NumberMFCD00274549
Melting Point141℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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