CAS 863588-32-3; sr1848

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CAS:

863588-32-3

分子式:

C₂₀H₂₅ClN₄O₂

分子量:

388.897

英文名称:

sr1848

ml180

6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1h,3h)-pyrimidinedione

cdi 3238389

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

H964616

MACKLIN

6-(4-(3-氯苯基)哌嗪-1-基)-3-环己基嘧啶-2,4(1H,3H)-二酮

98%

619元/50mg; 1121元/100mg; 2284元/250mg;

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储存：室温, 密封, 干燥, 惰性气体
状态：白色到米黄色粉末

SML1513

Sigma-Aldrich

SR1848

≥98% (HPLC)

1260.64元/5 MG; 5077.25元/25 MG;

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产品说明

应用

SR1848 has been used as a liver receptor homolog 1 (LRH-1) inhibitor to study the role of LRH-1 in the regulation of lipopolysaccharide (LPS)-induced proinflammatory cytokines in mice macrophage. It has also been used as an LRH-1 inhibitor to study its effects on activation-induced Fas ligand (FasL) expression in the murine T-cell hybridoma cell line.

包装

5, 25 mg in glass bottle

生化/生理作用

SR1848 is a cell penetrant and potent inhibitor of orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) that reduces the expression of CyclinD1 and E1, which results in inhibition of cell proliferation. SR1848 induces rapid translocation of nuclear LRH-1 to the cytoplasm.
The actions of SR1848 might contribute to anti-cancer functionality.

基本信息

经验(实验)分子式	C₂₀H₂₅ClN₄O₂
分子量	388.89
MDL编号	MFCD05894342
PubChem化学物质编号	329825930

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	O=C(N(C1CCCCC1)C(N2)=O)C=C2N3CCN(C4=CC(Cl)=CC=C4)CC3
InChI	1S/C20H25ClN4O2/c21-15-5-4-8-17(13-15)23-9-11-24(12-10-23)18-14-19(26)25(20(27)22-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,22,27)
InChI key	CHMQQIFPOIZPIJ-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

547695

Fluorochem

6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

98+%

11154元/250mg; 27786元/1g;

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基本信息

CAS Number	863588-32-3
MDL Number	MFCD05894342

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