产品说明

应用

PK 11195 已被用作胚胎原始红细胞和骨肉瘤细胞质杂交体中外周苯二氮卓受体(PBR)类似物的抑制剂。它还被用作心脏组织切片体外放射自显影实验中的未标记竞争性结合剂。

包装

10 mg in poly bottle
50 mg in glass bottle

生化/生理作用

PK 11195是一种外周苯二氮卓拮抗剂。它还是人组成型雄烷受体(hCAR)和人孕烷 X 受体(PXR)的拮抗剂。在人原代肝细胞中，PK 11195通过反甲基化诱导对受体hCAR的激动剂功能。PK 11195还是B细胞淋巴瘤2(Bcl-2)的拮抗剂，有望成为线粒体靶向治疗和肝胆管型肝癌治疗的化合物。

基本信息

产品性质

安全信息

基本信息

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .