| CAS: | 853299-07-7 | |
| 分子式: | C24H26F3N7O2 | |
| 分子量: | 501.5 | |
| 英文名称: |
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| 用途: | K03861是II型 CDK2 抑制剂，作用于CDK2(WT)，CDK2(C118L)，CDK2(A144C)，和 CDK2(C118L/A144C)的 Kd 分别为 50 nM，18.6 nM，15.4 nM，和 9.7 nM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||
| K792405 | MACKLIN | K03861 | 10mM in DMSO | 798元/1ml; | 展开 | ||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||
| K873118 | MACKLIN | K03861 | 99% | 112元/5mg; 504元/25mg; 1271元/100mg; 2145元/250mg; | 展开 | ||||||||||||||||||||||||||||
储存：-20℃ 状态：粉末 | |||||||||||||||||||||||||||||||||
| SML2971 | Sigma-Aldrich | K03861 | ≥98% (HPLC) | 949.53元/5 MG; 3828.18元/25 MG; | 展开 | ||||||||||||||||||||||||||||
产品说明 生化/生理作用 K03861 is an ATP site-binding, cyclin-competitive, type II CDK2 inhibitor that selectively targets and locks the kinase in its inactive DFG-out conformation (CDK2 Kd = 50 nM, DFG-out stabilizing CDK2-C118L/A144C mutant Kd = 9.7 nM without vs. 134.1 nM with bound cycB; CDK2-C118L/A144C-cycA IC50 = 0.8 μM), rendering it incompatible for cyclin bining. K03861 selectively inhibits CDK2-C118L/A144C over CycA-bound wt CDK2 by in vitro kinase assay (IC50 = 0.8 vs. >10 μM) and inhibits the proliferation of immortalized multipotent otic progenitor (iMOP) murine cell line (by 81% and 92%, resepectively, at 0.1 and 1.0 μM). 基本信息
产品性质
安全信息
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