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CAS: 851814-28-3
英文名称: 
piaa
(e)-3-(3-phenylbenzo[c]isoxazol-5-yl)acrylic acid
3-(3-phenyl-2,1-benzisoxazol-5-yl)-2-propenoic acid
推荐供应商
货号品牌产品名称规格包装、参考价格
SML2564Sigma-AldrichPIAA≥98% (HPLC)1168.11元/5 MG;   4684.02元/25 MG;   咨询

产品说明

生化/生理作用

PIAA is an inhibitor of TANK binding kinase 1 (TBK1) and IKB kinase epsilon (IKKε) that has been shown to promote regeneration of pancreatic β-cells. PIAA improved function and replication of mammalian β-cells including primary human β-cells and induced β-cell proliferation in streptozotocin-induced diabetic mice resulting in increased pancreas insulin content and improved glycemic control. PIAA exhibited an IC50 value of 400 nM for TBK1 and 1.07 μM for IKKε with minimum toxicity

基本信息

经验(实验)分子式C16H11NO3
分子量265.26

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear (warmed)
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
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