| CAS: | 844639-57-2 | |||||||||
| 分子式: | C21H21FN2O4S | |||||||||
| 分子量: | 416.47 | |||||||||
| 英文名称: |
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| 用途: | CAY10471 Racemate (TM30089 Racemate) 是一种有效、高度选择性的前列腺素 D2 受体 (CRTH2) 拮抗剂，对 hCRTH2 的 Ki 值为 0.6 nM，对其选择性远高于人血栓素 A2 受体 TP (Ki，>10000 nM) 或 PGD2 受体 DP (Ki，1200 nM)。CAY10471 Racemate 对小鼠和大鼠的同源 CRTH2 也具有拮抗作用。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||
| C877115 | MACKLIN | CAY10471 Racemate | ≥99% | 953元/5mg; 1559元/10mg; | 咨询 | ||||||||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||||||||
| SML2743 | Sigma-Aldrich | TM30089 | ≥98% (HPLC) | 1364.72元/5 MG; 5482.04元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||
产品说明 生化/生理作用 TM30089 is a ramatroban analog and an orally active, high-affinity, potent and selective prostaglandin D2 receptor 2 (DP2; CRTH2) antagonist (Ki = 0.6 nM/hDP2 against 1.2 nM PGD2; Ki = 1.2 μM/hDP1 against 0.5 nM PGD2, >10 μM/hTP against 5 nM SQ29548) that blocks PGD2-induced responses in hDP2 transfectants (IP1/βarr IC50 = 1.2/3.0 nM) and exhibits in vivo efficacy in a murine model of renal tubulointerstitial fibrosis (20 mg/kg b.i.d. p.o., starting 4 days before or 3 days after unilateral ureteral obstruction/UUO). 基本信息
产品性质
安全信息
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