CAS 83373-60-8; D609钾盐; d 609

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产品名称

规格

包装、参考价格

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D877166

MACKLIN

D609

98%

431元/5mg; 802元/10mg;

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储存：2-8℃
状态：灰白色到黄色粉末

293556

J&K

D609 potassium salt

98%

2055元/5MG; 8068元/25MG;

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基本信息

分子式	C₁₁H₁₅KOS₂
分子量	266.46
MDL编码	MFCD00171401
EINECS 编号	280-379-9
存储条件	Freezer -20℃

安全信息

图形或危害标志
提示语	Warning
危险说明	H302
防范说明	P262
WGK	3

251400

Sigma-Aldrich

D609, Potassium Salt-CAS 83373-60-8-Calbiochem

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (K_i = 5-10 µM).

3736.22元/5 MG;

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产品说明

一般描述

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (K_i = 5-10 µM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane.
Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, K_i= 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A₂, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).

包装

5 mg in Plastic ampoule

生化/生理作用

Primary Target
pc-specificphopholipase c
Product does not compete with ATP.
Reversible: no
Target K_i: 5-10 µM against phosphatidylcholine (PC)-specific phospholipase C
Cell permeable: no

警告

Toxicity: Standard Handling (A)

制备说明

tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.

重悬

Material is very labile once in solution (1.5 day half-life in tissue culture medium).

其他说明

Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J.328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses8, 245.
Schutze, S., et al. 1992. Cell71, 765.
Sauer, G., et al. 1990. Cancer Lett.53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun.162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol.36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA81, 3263.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₁H₁₅OS₂ · K
分子量	266.46
MDL编号	MFCD00171401

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic)
颜色	off-white
溶解性	DMSO: 25 mg/mL water: 25 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);
InChI key	YFUFHKMDCZBHMY-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

T8543

Sigma-Aldrich

O-Tricyclo[5.2.1.0^2,6]dec-9-yl dithiocarbonate potassium salt

≥95%, solid

2440.31元/5 MG; 9772.83元/25 MG;

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产品说明

应用

D609已被用作小鼠骨髓衍生的单核细胞中磷脂酰胆碱特异性磷脂酶C(PC-PLC)抑制剂。据报道，D609可以显著降低载脂蛋白 E^-/-小鼠中磷脂酰乙醇胺结合蛋白1(PEBP1)的水平升高。

包装

5 mg in glass bottle
25 mg in poly bottle

生化/生理作用

D609可以阻止细胞中二酰基甘油(DAG)的产生。D609通过抑制磷脂酶C介导的磷脂酰胆碱和其他甘油磷脂中存在的磷酸酯键的水解而起作用。
磷脂酰胆碱特异性磷脂酶C (PLC)和HIV-1抑制剂。黄原酸酯衍生物具有体外抗肿瘤活性。

制备说明

O-三环[5.2.1.0^2,6]癸-9-基二硫代碳酸酯或D609以50 mg / ml的速度溶于水，并产生透明至微浑浊，无色至浅黄色溶液。它也可溶于丙酮。但不溶于醚和烃。

由于可能发生酯交换反应，因此不应制备酒精溶液。该产物在溶液中非常不稳定(在组织培养基中半衰期为1.5天)，并且在pH低于6.0时容易水解。因此，应在使用前立即配制溶液，并且必须丢弃未使用的溶液。对于组织培养制剂，培养基应缓冲至pH 6.0-7.5。不得使用HEPES缓冲液，因为它会使本产品有毒。

基本信息

经验(实验)分子式	C₁₁H₁₅KOS₂
分子量	266.46
EC 号	280-379-9
MDL编号	MFCD00171401
PubChem化学物质编号	24278031
NACRES	NA.77

产品性质

质量水平	200
生物来源	synthetic (organic)
测定	≥95%
形式	solid
颜色	off-white to yellow
溶解性	H₂O: soluble 50 mg/mL, clear to slightly hazy, colorless to faintly yellow acetone: easily soluble diethyl ether: insoluble hydrocarbons: insoluble
SMILES string	[K]SC(=S)OC1CC2CC1C3CCCC23
InChI	1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);/q;+1/p-1/t6-,7?,8?,9-,10?;/m1./s1
InChI key	IGULCCCBGBDZKQ-HJPGVBIPSA-M

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)