| CAS: | 831234-13-0 | ||
| 分子式: | C19H17N3O | ||
| 分子量: | 303.36 | ||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||
| A937702 | MACKLIN | AC 1903 | ≥98%(HPLC) | 312元/5mg; 646元/25mg; 1866元/100mg; | 咨询 | ||||||||||||||||||||||||||||||
储存：2-8°C，密封，干燥 | |||||||||||||||||||||||||||||||||||
| A793504 | MACKLIN | AC 1903 | 10mM in DMSO | 240元/1ml; | 咨询 | ||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||
| SML2244 | Sigma-Aldrich | AC1903 | ≥98% (HPLC) | 1073.15元/5 MG; 4332.77元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||
产品说明 应用 AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma. 生化/生理作用 AC1903 is a specific inhibitor of TRPC5, the transient receptor potential canonical channel 5, a Ca2+ permeable nonselective cation channel highly expressed in brain and kidney. AC1903 did not inhibit TRPC4 or TRPC6 currents and showed no off-target effects in kinase profiling assays. It specifically blocked TRPC5 channel activity in glomeruli of proteinuric rats, suppressed severe proteinuria, showing a therapeutic benefit in a rat model of hypertensive proteinuric kidney disease. 基本信息
产品性质
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