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关键词:       仅模糊查询
CAS: 83-07-8
分子式: C11H13N3O
分子量: 203.24
沸点: 340°C
熔点: 105-110 °C(lit.)
中文名称: 
1,5-二甲基-2-苯基-4-氨基-3-吡唑啉酮
1,5-二甲基-2-苯基-4-氨基-3-吡唑酮
4-氨基安替比林
4-氨基非那宗
4-氨基-1,2-二氢-1,5-二甲基-2-苯基-3H-吡唑-3-酮
4-氨基安替比林结晶
4-氨基安替吡啉
1,5二甲基-2-苯基-4-氨基-3-吡唑啉酮
4-氨基-2,3-二甲基-1-苯基代吡唑啉酮-[5]
英文名称: 
4-Amine-2,3-dimethyl-lphenyl-5-pyrazolone-[5],Ampyrone
1-Phenyl-2,3-dimethyl-4-aminopyrazloone-[5]
4-Aminoantipyrine
4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-Pyrazol-3-one
4-Aminophenazone
4-amino-antipyrin
1,5-dimethyl-2-phenyl-4-aminopyrazoline
4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on
4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on
4-aap
4-aminoantipyrene
4-amminoantipirina
aminoantipyrin
aminoantipyrine
aminoazophenazone
ampyrone
metapirazone
solnapyrin-a
4-Aminoantipyrine;4-aminophenazone
4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
3H-Pyrazol-3-one,4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-
展开更多英文名
性质描述: 淡黄色结晶。熔点109℃。溶于水、苯和乙醇，微溶于乙醚。
生产方法: 安替比林经亚硝酸钠亚硝化，经亚硫酸氢铵与亚硫酸铵还原，经硫酸水解，最后用液氨中和，得到4-氨基安替比林。工艺过程如下：安替比林与50%硫酸配成溶液，其中含安替比林38%-40%、含硫酸11%-12%。将此溶液与亚硝酸钠溶液同时流入亚硝化反应器，控制两者的流量，控制反应温度45-50℃，搅拌下反应，并用碘粉淀粉试纸测反应终点以调节水流量。亚硝化生成的亚硝基安替比林立即流入还原罐，与罐内配好的还原剂亚硫酸氢铵与亚硫酸铵的水溶液反应。取样测pH值及还原度，pH值在5.4-5.8之间，还原度约为15（即1ml还原液消耗0.1N碘液的毫升数）。还原结束后，pH值调节至5.8-6.0，还原度为5左右。升温至100℃，水解3h。降温至80℃，用液氨中和至pH7-7.5，静置分层。分去废水，得4-氨基安替比林油（含量80%以上）。将其压入结晶罐，搅拌、冷却结晶、过滤，得4-氨基安替比林。收率96%。
用途: 医药安乃近的中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
A902513MACKLIN4-氨基安替吡啉for spectrophotometric det. of H2O2 and phenols, ≥98.0%49元/5g;   146元/25g;   379元/100g;   1375元/500g;   展开
储存：室温
状态：白色到浅黄色粉末或晶体
A800471MACKLIN4-氨基安替比林98%75元/25g;   208元/100g;   882元/500g;   4232元/2.5kg;   展开
储存：室温
状态：淡黄色到棕色粉末
A0256TCI4-Aminoantipyrine>99.0%(GC)(T)280元/25G;   785元/100G;   2590元/500G;   展开

基本信息

纯度/分析方法>99.0%(GC)(T)
分子式/分子量C11H13N3O = 203.25
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气
Reaxys-RN181635
PubChem物质ID87561911
SDBS (AIST Spectral DB)5949
Merck Index (14)591
MDL编号MFCD00003145

技术规格

AppearanceLight yellow to Yellow to Orange powder to crystalline
Purity(GC)min. 99.0 %
Purity(Nonaqueous Titration)min. 99.0 %
Melting point107.0 to 110.0 ℃

物性(参考值)

熔点109 ℃
水溶性可溶
溶解性(可溶于)乙醇,苯,氯仿
溶解度(极微溶)乙醚

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

相关法规

RTECS#CD2480000
A2254TCI4-Aminoantipyrine [for Biochemical Research]>98.0%(T)255元/1G;   630元/5G;   展开

基本信息

纯度/分析方法>98.0%(T)
分子式/分子量C11H13N3O = 203.25
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气
Reaxys-RN181635
PubChem物质ID87561316
SDBS (AIST Spectral DB)5949
Merck Index (14)591
MDL编号MFCD00003145

技术规格

AppearanceWhite to Light yellow to Light orange powder to crystal
Purity(GC)min. 97.0 %
Purity(Nonaqueous Titration)min. 98.0 %
Melting point107.0 to 111.0 ℃
Hydrogendioxide detection test(Peroxidase method)to pass test

物性(参考值)

熔点109 ℃

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

相关法规

RTECS#CD2480000
602529J&K4-Aminoantipyrine98%118元/25G;   309元/100G;   931元/500G;   展开

基本信息

分子式C11H13N3O
分子量203.24
熔点105-110
密度0.800
MDL编码MFCD00003145
Beilstein181635
Merck14,591
EINECS 编号201-452-3

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
RTECSCD2480000
TSCA是
A13846Alfa Aesar4-Aminoantipyrine97%796元/100g;   3068元/500g;   12031元/2500g;   展开

应用
4-Aminoantipyrine shows both analgesic and anti-inflammatory properties. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is used as a drug dipyrone.

备注
Incompatible with Strong oxidizing agents, strong acids, acid chlorides, acid anhydrides.

基本信息

MDL
MFCD00003145

EINECS
201-452-3

分子式
C11H13N3O

分子量
203.25

熔点
106-110°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water. 500 g/L (20°C), methanol. Partially soluble in diethyl ether.

Beilstein
181635

Merck
14,591

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H315-H319-H335
Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
26-36/37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
CD2480000

TSCA
是

C10315Alfa Aesar4-Aminoantipyrine98%457元/25g;   774元/100g;   1824元/500g;   9971元/2.5kg;   展开

基本信息

Ref#
10315

MDL
3145

分子式
C11 H13 N3 O

分子量
203.25

密度
0.8

形态
Yellow to pale brown powder

O1123-100Alfa Aesar4-AMINOANTIPYRINE CERT 100G1284元/100g;   展开

基本信息

Ref#
F53476

1.07293Supelco4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-oneGR for analysis1052.8元/10 G;   4911.48元/100 G;   展开

产品说明

分析说明

Assay (perchloric acid titration): ≥ 99
Identity (IR-spectrum): passes test
Melting point: 107 - 109
Sulfated ash: ≤ 0.1 %
Loss on drying (90 °C): ≤ 0.5 %
Sensitivity test (to phenol): passes test

基本信息

经验(实验)分子式C11H13N3O
分子量203.24
MDL编号MFCD00003145
EC索引号201-452-3

产品性质

质量水平100
效能1700 mg/kg LD50, oral (Rat)
pH值(酸碱度)7.1 (20 ℃, 100 g/L in H2O, slurry)
mp107-109 ℃
溶解性 56 g/L
堆积密度430 kg/m3
储存温度15-25℃
InChI1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3
InChI keyRLFWWDJHLFCNIJ-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
06800Supelco4-Aminoantipyrinefor spectrophotometric det. of H2O2 and phenols, ≥98.0%571.93元/25G;   1590.62元/100G;   5314.28元/500G;   展开

产品说明

其他说明

测定 H2O2 的试剂
采用电化学阻抗谱 (EIS)、动电位极化和失重等技术，研究了 4-氨基安替比林在 2 MHCl 溶液中对低碳钢的缓蚀作用。

基本信息

经验(实验)分子式C11H13N3O
分子量203.24
Beilstein181635
EC 号201-452-3
MDL编号MFCD00003145
PubChem化学物质编号329748282
NACRESNA.21

产品性质

质量水平100
测定≥98.0% (NT)
≥98.0%
质量for spectrophotometric det. of H2O2 and phenols
technique(s)HPLC: suitable
UV/Vis spectroscopy: suitable
photometry: suitable
mp105-110 ℃ (lit.)
108-110 ℃
溶解性H2O: 0.1 g/mL, clear to slightly hazy
SMILES stringCN1N(c2ccccc2)C(=O)C(N)=C1C
InChI1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3
InChI keyRLFWWDJHLFCNIJ-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
33528Sigma-Aldrich4-Aminoantipyrinepuriss. p.a., reag. Ph. Eur., ≥99%1400.34元/25 G;   2834.63元/100 G;   展开

产品说明

一般描述

4-氨基安替比林通过与各种醛和肟反应形成杂环席夫碱。这些席夫碱与转换金属形成稳定的络合物。

基本信息

经验(实验)分子式C11H13N3O
分子量203.24
Beilstein181635
EC 号201-452-3
MDL编号MFCD00003145
PubChem化学物质编号57648860
NACRESNA.21

产品性质

质量水平200
agencyUSP/NF
reag. Ph. Eur.
等级puriss. p.a.
测定≥99%
灼烧残渣≤0.1%
缺失≤0.5% loss on drying
mp105-110 ℃ (lit.)
107-109 ℃
SMILES stringCN1N(c2ccccc2)C(=O)C(N)=C1C
InChI1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3
InChI keyRLFWWDJHLFCNIJ-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
A4382Sigma-Aldrich4-Aminoantipyrinereagent grade230元/10 G;   499.95元/25 G;   531.94元/50 G;   562.2元/100 G;   811.23元/250 G;   展开

产品说明

包装

10, 25, 50, 100, 250 g in glass bottle

应用

在苯酚和过氧化物酶存在的情况下测定葡萄糖的试剂。

基本信息

经验(实验)分子式C11H13N3O
分子量203.24
Beilstein181635
EC 号201-452-3
MDL编号MFCD00003145
PubChem化学物质编号24890855
NACRESNA.31

产品性质

质量水平300
等级reagent grade
测定≥97% (HPLC)
形式powder
mp105-110 ℃ (lit.)
溶解性water: 50 mg/mL
SMILES stringCN1N(c2ccccc2)C(=O)C(N)=C1C
InChI1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3
InChI keyRLFWWDJHLFCNIJ-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
PHR2784SupelcoMetamizole Impurity BPharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100 mg8473.25元/100 MG;   展开

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC6282in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C11H13N3O
分子量203.24
Beilstein181635
MDL编号MFCD00003145

产品性质

等级certified reference material
pharmaceutical secondary standard
形式powder
包装pkg of 100 mg
mp105-110 ℃ (lit.)
储存温度2-8℃
SMILES stringCN1N(c2ccccc2)C(=O)C(N)=C1C
InChI1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3
InChI keyRLFWWDJHLFCNIJ-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
43827Supelco4-Aminoantipyrineanalytical standard1214.83元/100 MG;   展开

产品说明

一般描述

4-氨基安替比林是一种非甾体抗炎药(NSAID)。它是一种PGE2依赖性阻断剂和环氧合酶(COX)抑制剂。

应用

有关合适的仪器技术的更多信息，请参阅产品的分析证书。想要获得更多支持，请联系技术服务部。

基本信息

经验(实验)分子式C11H13N3O
分子量203.24
Beilstein181635
EC 号201-452-3
MDL编号MFCD00003145
PubChem化学物质编号329756413
NACRESNA.24

产品性质

质量水平100
等级analytical standard
测定≥99.0% (HPLC)
保质期limited shelf life, expiry date on the label
technique(s)HPLC: suitable
gas chromatography (GC): suitable
缺失≤0.5% loss on drying
mp105-110 ℃ (lit.)
application(s)environmental
pharmaceutical
格式neat
SMILES stringCN1N(c2ccccc2)C(=O)C(N)=C1C
InChI1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3
InChI keyRLFWWDJHLFCNIJ-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
990727Amethyst4-Aminoantipyrine98%, 试剂级48元/25G;   163元/100G;   588元/500G;   展开

基本信息

分子式C11H13N3O
分子量203.24
熔点105-110
密度0.800
MDL编码MFCD00003145
Beilstein181635
Merck14,591
EINECS 编号201-452-3

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
RTECSCD2480000
TSCA是
358185Fluorochem4-Amino-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one95%308元/25g;   572元/100g;   2464元/500g;   展开

基本信息

CAS Number83-07-8
MDL NumberMFCD00003145
Melting Point108℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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