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CAS: 826-39-1
分子式: C11H21N.HCl
分子量: 203.75
英文名称: 
n,2,3,3-tetramethyl-2-norbornanamin hydrochloride
3-methylaminoisocamphane hydrochloride
3-methylaminoisokamfan chlorid
inversine hydrochloride
mecamine hydrochloride
mecamylamine hydrochloride
mekamin hydrochloride
mevasin hydrochloride
n,2,3,3-tetramethyl-2-norbornanamine hydrochloride
n-methyl-dl-isobornylamine hydrochloride
n-methyl-n-2,5-endomethylene-1,6,6-trimethylcyclohexylamine hydrochloride
展开更多英文名
用途: Mecamylamine Hydrochloride is a noncompetitive and nonselective antagonist of AChRs. The compound preferentially blocks nicotinic receptors at autonomic ganglia and is able to cross the blood brain barrier. Once across the blood brain barrier Mecamylamine Hydrochloride can selectively antagonize neuronal AChRs. Mecamylamine Hydrochloride is an inhibitor of AChR α 3, AChR α 4, AChR α 7 and AChRβ2.
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状态:白色粉末
M9020Sigma-AldrichMecamylamine hydrochloride761.5元/5 MG;   3072.39元/25 MG;   7425.04元/100 MG;   咨询

产品说明

应用

在电流钳记录期间,美卡拉明盐酸盐已被用作细胞外盐水中的添加剂以减少突触输入。它还被用作主动脉体神经元和 MLO-Y4 细胞中的非选择性烟碱乙酰胆碱受体阻断剂。

包装

5, 25, 100 mg in glass bottle

生化/生理作用

非竞争性烟碱乙酰胆碱受体拮抗剂;优先阻断自主神经节的烟碱受体;穿过血脑屏障。

特点和优势

该化合物由 AstraZeneca 公司开发。若要浏览其他制药公司研发的化合物和批准的药物/候选药物列表,请单击此处。
该化合物已被列于《受体分类和信号转导手册》的乙酰胆碱受体(烟碱)页面中。若要浏览手册其他页面,请单击此处。

注意

溶液在高压灭菌时稳定。

基本信息

经验(实验)分子式C11H21N · HCl
分子量203.75
EC 号212-555-8
MDL编号MFCD00151462
PubChem化学物质编号24277851
NACRESNA.77

产品性质

质量水平200
溶解性ethanol: 122 mg/mL
H2O: 47 mg/mL
isopropanol: 476 mg/mL
glycerol: 95 mg/mL
创始人AstraZeneca
SMILES stringCl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C
InChI1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1
InChI keyPKVZBNCYEICAQP-CIISUUNXSA-N
Gene Informationhuman ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P264 - P270 - P301 + P310 - P405 - P501
危险分类Acute Tox. 3 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
1376006USPMecamylamine hydrochlorideUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C11H21N · HCl
分子量203.75
MDL编号MFCD00151462
PubChem化学物质编号329750330
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C
InChI1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1
InChI keyPKVZBNCYEICAQP-CIISUUNXSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P301 + P330 + P331 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
391780FluorochemN,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride95%8998元/1g;   咨询

基本信息

CAS Number826-39-1
MDL NumberMFCD00151462

安全信息

图形或危害标志
危险性说明 H301: Toxic if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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