| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| G838238 | MACKLIN | 更昔洛韦 | ≥99 % HPLC, powder | 76元/1g; 166元/5g; 509元/25g; 1359元/100g; | 咨询 |
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| G871935 | MACKLIN | 更昔洛韦 | 98% | 30元/1g; 58元/5g; 127元/25g; 494元/100g; | 咨询 |
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| G794577 | MACKLIN | 更昔洛韦 | 10mM in DMSO | 441元/1ml; | 咨询 |
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| G0315 | TCI | Ganciclovir | >98.0%(T)(HPLC) | 100元/5G; 360元/25G; | 咨询 |
基本信息 | 纯度/分析方法 | >98.0%(T)(HPLC) | | 分子式/分子量 | C9H13N5O4 = 255.23 | | 外观与形状(20℃) | 固体 | | 储存温度 | 0-10℃ | | 应避免的情况 | 加热 | | Reaxys-RN | 3654487 | | PubChem物质ID | 160871351 | | Merck Index (14) | 4363 | | MDL编号 | MFCD00870588 |
技术规格 | Appearance | White to Almost white powder to crystal | | Purity(HPLC) | min. 98.0 area% | | Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on dried substance) | | Drying loss | max. 4.0 % |
物性(参考值) | 熔点 | 250 ℃(dec.) | | 水溶性 | 实际上不溶 | | 在水中的溶解度 | 4.3 g/l 25 ℃ |
安全信息 | 图形或危害标志 |  | | 信号词 | 危险 | | 危险性说明 | H360 : 可能对生育能力或胎儿造成伤害。
H340 : 可能造成遗传性缺陷。
H351 : 怀疑致癌。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑：求医/就诊。
P405 : 存放处须加锁。
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相关法规 |
| 232823 | J&K | Ganciclovir | 99%, 抗1型猫科疱疹病毒化合物 | 212元/1g; 846元/5G; | 咨询 |
基本信息 | 分子式 | C9H13N5O4 | | 分子量 | 255.23 | | MDL编码 | MFCD00870588 | | 存储条件 | Store at 2-8℃ |
安全信息 | 图形或危害标志 | | | 提示语 | Danger | | 危险说明 | H360 | | 防范说明 | P201
P308+P313 | | WGK | 3 | | RTECS | MF8407000 |
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| PHR1593 | Supelco | Ganciclovir | Pharmaceutical Secondary Standard; Certified Reference Material | 2391.32元/1 G; | 咨询 |
产品说明 一般描述 Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ganciclovir is a nucleoside analog which is utilized extensively for the remedy of cytomegalovirus infections. It is also found to be efficient in the treatment of cytomegalovirus in immunocompromised patients, particularly against acquired immunodeficiency syndrome (AIDS) and congenital immunodeficiency. 应用 Ganciclovir may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. 分析说明 These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. 其他说明 This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. 附注 To see an example of a Certificate of Analysis for this material enter LRAB3691 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. 基本信息 | 经验(实验)分子式 | C9H13N5O4 | | 分子量 | 255.23 | | MDL编号 | MFCD00870588 | | PubChem化学物质编号 | 329823497 | | NACRES | NA.24 |
产品性质 | 质量水平 | 300 | | 等级 | certified reference material
pharmaceutical secondary standard | | CofA | current certificate can be downloaded | | 包装 | pkg of 1 g | | technique(s) | HPLC: suitable
gas chromatography (GC): suitable | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 药典可追溯性 | traceable to PhEur Y0001129
traceable to USP 1288306 | | 储存温度 | 2-8℃ | | SMILES string | NC1=Nc2c(ncn2COC(CO)CO)C(=O)N1 | | InChI | 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) | | InChI key | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H340 - H361fd | | 预防措施声明 | P201 - P308 + P313 | | 危险分类 | Muta. 1B - Repr. 2 | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| Y0001129 | | Ganciclovir | European Pharmacopoeia (EP) Reference Standard | 1277.32元/ ; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 120 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C9H13N5O4 | | 分子量 | 255.23 | | MDL编号 | MFCD00870588 | | PubChem化学物质编号 | 329831279 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | NC1=Nc2c(ncn2COC(CO)CO)C(=O)N1 | | InChI | 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) | | InChI key | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H340 - H361fd | | 预防措施声明 | P201 - P308 + P313 | | 危险分类 | Muta. 1B - Repr. 2 | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| SML2346 | Sigma-Aldrich | Ganciclovir ready made solution | ≥99% (HPLC), 10 mM in DMSO | 957.53元/1 ML; | 咨询 |
产品说明 应用 Ganciclovir ready-made solution has been used in combination with resveratrol to study its effect on melanoma cells. It has also been used as a synthetic substrate for viral thymidine kinase to study its effects on human-inducible pluripotent stem cells. 生化/生理作用 Ganciclovir is a nucleoside guanosine analog that contains an active moiety, ganciclovir triphosphate. This active moiety can inhibit viral replication by interrupting the viral DNA during elongation. Ganciclovir is a potent agent in preventing cytomegalovirus (CMV) retinitis disease in human immunodeficiency virus (HIV) patients. It exhibits therapeutic effects against CMV disease involving the lungs, liver, and gastrointestinal tract. Ganciclovir can be enzymatically phosphorylated to an active triphosphate analog by herpes simplex virus thymidine kinase (HSV-TK) or host-encoded deoxyguanosine kinase. It has the potential to treat allogeneic bone marrow, kidney, heart, liver, and lung transplantations. 其他说明 Ganciclovir ready made solution in DMSO is provided at 10mM concentration (2.55mg/mL). It is suggested to dilute the provided ready made solution to a working concentration of 2-100μM for cell culture applications. 基本信息 | 经验(实验)分子式 | C9H13N5O4 | | 分子量 | 255.23 | | MDL编号 | MFCD12197280 | | NACRES | NA.77 |
产品性质 | 测定 | ≥99% (HPLC) | | 形式 | DMSO solution | | 浓度 | 10 mM in DMSO | | 储存温度 | 2-8℃ | | InChI | 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) | | InChI key | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H340 | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Muta. 1B | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 2 | | 闪点(F) | 188.6 °F - closed cup | | 闪点(C) | 87 ℃ - closed cup |
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| G2536 | Sigma-Aldrich | Ganciclovir | ≥99% (HPLC), powder | 5466.23元/100 MG; | 咨询 |
产品说明 一般描述 化学结构：核苷 应用 分子生物学中，当需要对目的基因进行同源重组时，更昔洛韦可用于选择随机重组事件。 包装 100 mg in poly bottle 生化/生理作用 更昔洛韦是一种前药核苷类似物，通过磷酸化激活。可用于癌症研究中基因治疗的研究。
在编码胸苷激酶的病毒自杀基因表达后，无毒前药转化成磷酸化的活性类似物并掺入复制真核细胞的DNA中，导致恶性分裂细胞死亡。在G2-M检查点不可逆转地阻滞细胞周期。研究了间隙连接在更昔洛韦旁观者效应中的参与情况。更昔洛韦用于研究端粒丢失 和评估病毒对抗病毒治疗的敏感性。 特点和优势 该化合物由 Roche开发。想浏览其他制药公司开发的化合物和已批准药物/候选药物目录， 请单击此处。
该化合物是ADME Tox研究的特色产品。点击此处 了解更多ADME Tox的特色产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。 基本信息 | 经验(实验)分子式 | C9H13N5O4 | | 分子量 | 255.23 | | MDL编号 | MFCD00870588 | | PubChem化学物质编号 | 24278453 | | NACRES | NA.77 |
产品性质 | 质量水平 | 300 | | 测定 | ≥99% (HPLC) | | 形式 | powder | | 颜色 | white | | 溶解性 | 0.1 M HCl: 10 mg/mL | | ε (extinction coefficient) | 12.0 at 256 nm at 1 mM | | 作用机制 | DNA synthesis | interferes | | 抗生素抗菌谱 | viruses | | 创始人 | Roche | | 储存温度 | 2-8℃ | | SMILES string | NC1=Nc2c(ncn2COC(CO)CO)C(=O)N1 | | InChI | 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) | | InChI key | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H340 - H361fd | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Muta. 1B - Repr. 2 | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
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| 1288306 | USP | Ganciclovir | United States Pharmacopeia (USP) Reference Standard | 7584.83元/200 MG; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia. 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here.
Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C9H13N5O4 | | 分子量 | 255.23 | | MDL编号 | MFCD00870588 | | PubChem化学物质编号 | 329749927 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | NC1=Nc2c(ncn2COC(CO)CO)C(=O)N1 | | InChI | 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) | | InChI key | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H340 - H361fd | | 预防措施声明 | P201 - P308 + P313 | | 危险分类 | Muta. 1B - Repr. 2 | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 345700 | Sigma-Aldrich | Ganciclovir-CAS 82410-32-0-Calbiochem | A nucleoside analog structurally related to Acyclovir. | 3298.89元/50 MG; | 咨询 |
产品说明 一般描述 A nucleoside analog that is structurally related to Acyclovir (Cat. No. 114798). Acts as a pro-drug that is activated by phosphorylation. It has been used in the study of "suicide gene therapy" in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus thymidine kinase (TK), the non-toxic pro-drug is converted to the phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the dividing malignant cells. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Has also been used to study the loss of telomers and to evaluate the sensitivity of viruses to anti-viral agents.
A nucleoside analog structurally related to Acyclovir (Cat. No. 114798). Acts as a prodrug that is activated by phosphorylation. Has been used in the study of “suicide” gene therapy in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents. 包装 50 mg in Glass bottle
Packaged under inert gas 生化/生理作用 Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Acts as a prodrug that is activated by phosphorylation 警告 Toxicity: Carcinogenic / Teratogenic (D) 重悬 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 其他说明 Aghi, M., et al. 2000. J. Gene Med.2, 148.
Qiao, J., et al. 2000. Hum. Gene Ther.11, 1569.
Cannon, J.S., et al. 1999. J. Virol.73, 4786.
Rubsam, L.Z., et al. 1999. Cancer Res.59, 669.
Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA96, 6781.
Yamasaki, H., et al. 1999. C.R. Acad. Sci. III322, 151.
Halloran, P.J., and Fenton, R.G. 1998. Cancer Res.58, 3855. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C9H13N5O4 | | 分子量 | 255.23 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze
desiccated | | 颜色 | white | | 溶解性 | water: 2 mg/mL
DMSO: 5 mg/mL | | 运输 | ambient | | 储存温度 | −20℃ | | InChI | 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) | | InChI key | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H340 - H361fd | | 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 | | 危险分类 | Muta. 1B - Repr. 2 | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 212141 | Fluorochem | 2-Amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1H-purin-6(9H)-one | 95% | 220元/1g; 550元/5g; 814元/10g; 1474元/25g; | 咨询 |
基本信息 | CAS Number | 82410-32-0 | | MDL Number | MFCD00870588 | | Melting Point | 250 ℃ |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H340: May cause genetic defects ..
H361fd: Reproductive toxicity
| | 防范说明 | P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P281: Use personal protective equipment as required.
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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