CAS 82248-59-7; 阿托莫西汀; Atomoxetine HCl

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产品名称

规格

包装、参考价格

详情

A792780

MACKLIN

盐酸托莫西汀

10mM in DMSO

808元/1ml;

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储存：-20°C
状态：白色至米白色固体

A837923

MACKLIN

盐酸托莫西汀

97 %

126元/1g; 505元/5g; 1815元/25g;

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储存：2-8℃，干燥
状态：白色到灰白色固体

A2357

TCI

Atomoxetine Hydrochloride

>98.0%(T)(HPLC)

550元/100MG; 1990元/1G;

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基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₁₇H₂₁NO・HCl = 291.82
外观与形状(20℃)	固体
储存温度	<0℃
应避免的情况	加热
包装和容器	1G-带有塑料内管的玻璃瓶 (查看图片)
相关CAS RN	83015-26-3
Reaxys-RN	5318974
PubChem物质ID	125307825
Merck Index (14)	863
MDL编号	MFCD06410992

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	167.0 to 171.0 ℃
Specific rotation [a]20/D	-41.0 to -44.0 deg(C=1, MeOH)

物性(参考值)

熔点	169 ℃
比旋光度 [α]D	-42° (C=1,MeOH)
溶解性(可溶于)	甲醇

506507

J&K

Atomoxetine Hydrochloride

99%, 一种选择性去甲肾上腺素重摄取抑制剂

241元/10mg; 897元/50MG;

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基本信息

分子式	C₁₇H₂₁NO·HCl
分子量	291.82
熔点	167-171
比旋光度([α]20D)	-44 to -41 (C=1, MeOH)
MDL编码	MFCD06410992
Beilstein	5318974
Merck	14,863
存储条件	Freezer -20℃

产品描述

Atomoxetine HCl是一种选择性的去甲肾上腺素(NE)转运体抑制剂，Ki为5 nM，作用于人体5-HT和DA转运体亲和力比其低15和290倍。

靶点（IC50 & Targe）

5-HT,77nM(Ki)

DA transporter,1451nM(Ki)

Norepinephrine (NE) transporter,5nM(Ki)

体外研究

Atomoxetine是一种选择性去甲肾上腺素重摄取抑制剂，Ki 为5 nM，而与5-羟色胺和多巴胺转运蛋白结合的Ki为77和1451 nM。[1]

体内研究

在微透析研究中，Atomoxetine 使前额皮质中细胞外(EX)去甲肾上腺素的水平增加3倍，但是不改变5-HTEX的水平。Atomoxetine也会使PFC中DAEX浓度增加3倍，但是不改变纹状体和伏隔核中的DAEX。Atomoxetine使PFC中Fos增加3.7倍，但不会改变纹状体和伏隔核中的Fos。[1]在动物中，Atomoxetine选择性抑制去甲肾上腺素在肾上腺素能神经元突触前的摄取，并且在抑郁的动物模型中也具有活性。[2][3]

参考文献

[1] Bymaster FP, et al. Neuropsychopharmacology, 2002, 27(5), 699-711.

[2] Zerbe RL, et al. J Pharmacol Exp Ther, 1985, 232(1), 139-143.

[3] Wong DT, et al. J Pharmacol Exp Ther, 1982, 222(1), 61-65.

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H410
防范说明	P264 P270 P273 P301+P312 P330 P391 P501
UN号码	3077
危险分类	9
包装等级	III
WGK	3

Y0001587

Atomoxetine for impurity A identification

European Pharmacopoeia (EP) Reference Standard

1861.35元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Norepinephrine uptake blocker.

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₇H₂₁NO · HCl
分子量	291.82
MDL编号	MFCD06410992
PubChem化学物质编号	329831497
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
InChI	1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
InChI key	LUCXVPAZUDVVBT-UNTBIKODSA-N
Gene Information	human ... SLC6A2(6530)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0001586

Atomoxetine Hydrochloride

European Pharmacopoeia (EP) Reference Standard

1572.27元/ ;

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产品说明

一般描述

生化/生理作用

Norepinephrine uptake blocker.

包装

Unit quantity: 110 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₇H₂₁NO · HCl
分子量	291.82
MDL编号	MFCD06410992
PubChem化学物质编号	329831496
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
InChI	1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
InChI key	LUCXVPAZUDVVBT-UNTBIKODSA-N
Gene Information	human ... SLC6A2(6530)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

T7947

Sigma-Aldrich

(R)-Tomoxetine hydrochloride

solid

5782.74元/25 MG; 14537.8元/100 MG;

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产品说明

应用

(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:

to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice
to study its effects on set shifting in rats
to study its effects on rat brain as a result of its long-term use

包装

25, 50, 100 mg in glass bottle

生化/生理作用

(R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters. It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC). (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter. It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).
Norepinephrine uptake blocker.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₁₇H₂₁NO · HCl
分子量	291.82
MDL编号	MFCD06410992
PubChem化学物质编号	24278760
NACRES	NA.77

产品性质

质量水平	100
形式	solid
创始人	Eli Lilly
储存温度	2-8℃
SMILES string	CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
InChI	1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
InChI key	LUCXVPAZUDVVBT-UNTBIKODSA-N
Gene Information	human ... SLC6A2(6530)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

PHR1679

Supelco

Atomoxetine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

1568.52元/500 MG;

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产品说明

一般描述

Atomoxetine hydrochloride is a nonstimulant used in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in children and adults.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Atomoxetine hydrochloride may be used as a pharmaceutical reference standard for the determination of atomoxetine hydrochloride in pharmaceutical formulations by spectrophotometric method.

生化/生理作用

Norepinephrine uptake blocker.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA6124 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₁₇H₂₁NO · HCl
分子量	291.82
MDL编号	MFCD06410992
PubChem化学物质编号	329823551
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
包装	pkg of 500 mg
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
InChI	1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
InChI key	LUCXVPAZUDVVBT-UNTBIKODSA-N
Gene Information	human ... SLC6A2(6530)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1044469

USP

Atomoxetine Hydrochloride

United States Pharmacopeia (USP) Reference Standard

8316.48元/200 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Norepinephrine uptake blocker.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₇H₂₁NO · HCl
分子量	291.82
MDL编号	MFCD06410992
PubChem化学物质编号	329749078

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
InChI	1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
InChI key	LUCXVPAZUDVVBT-UNTBIKODSA-N
Gene Information	human ... SLC6A2(6530)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

079413

Fluorochem

(R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride

95%

682元/250mg; 1364元/1g; 3674元/5g; 7282元/10g;

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基本信息

CAS Number	82248-59-7
MDL Number	MFCD06410992
Melting Point	169℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .