| CAS: | 81103-11-9 | |||||||
| 分子式: | C38H69NO13 | |||||||
| 分子量: | 747.96 | |||||||
| 中文名称: |
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| 英文名称: |
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| 性质描述: | 白色或类白色结晶体，无臭、味苦。在氯仿中易溶，在丙酮中略溶，在甲醇、乙醇、乙醚中微溶，在水中不溶。 | |||||||
| 用途: | 大环内酯类抗生素，用于治疗上、下呼吸道感染、皮下软组织感染等。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||||
| 767219 | MACKLIN | 克拉霉素标准溶液 | 100μg/mL in Acetonitrile | 711元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||
储存：2-8°C, 避光 | |||||||||||||||||||||||||||||||||||||||||||||||
| 767220 | MACKLIN | 克拉霉素标准溶液 | 100μg/mL in Methanol | 468元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||
储存：2-8°C, 避光 | |||||||||||||||||||||||||||||||||||||||||||||||
| 767221 | MACKLIN | 克拉霉素标准溶液 | 1000μg/mL in Methanol | 520元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||
储存：2-8°C, 避光 | |||||||||||||||||||||||||||||||||||||||||||||||
| 261815 | J&K | Clarithromycin | 95%, 一种大环内脂类抗生素和CYP3A4抑制剂 | 181元/1G; 342元/5G; 1420元/25G; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||
基本信息
产品描述 Clarithromycin 是一种大环内酯类抗生素，是CYP3A4抑制剂，用于治疗许多细菌感染。 靶点（IC50 & Targe） 50S ribosome MRP1 体外研究 Clarithromycin剂量依赖性抑制单核细胞和THP-1细胞中细菌诱导的白介素-8的产生。Clarithromycin调节三个其他启动子，其具有NF-kappa B或者AP-1结合序列:两个合成的(pAP-1-Luc和pNF-kappa B-Luc)和一个天然产生的(ELAM-Luc)。[1] Clarithromycin浓度相关性抑制U-937和Jurkat 细胞中TNF-alpha诱导的NF-kappaB活化。Clarithromycin抑制U-937，Jurkat，A549细胞，和PBMC中TNF-alpha诱导的，以及PBMC中SEA诱导的NF-kappaB活化。Clarithromycin防止U-937细胞中NF-kappaB依赖性报告基因的表达。[2] Clarithromycin显著抑制71%的每种细胞因子的产生，并显著增加29%的人单核细胞。[3] Clarithromycin以剂量和培育时间依赖的方式抑制肿瘤坏死因子(TNF)-alpha-诱导的IL-8基因表达。Clarithromycin抑制TNF-alpha处理的BET-1A细胞中AP-1结合。Clarithromycin主要通过人气道上皮细胞中AP-1结合位点抑制IL-8基因转录。[4] Clarithromycin抑制人鼻腔上皮细胞中流感嗜血杆菌内毒素(HIE)刺激的IL-1 beta基因表达。Clarithromycin抑制鼻腔成纤维细胞中IL-1 beta刺激的细胞间黏附因子-1基因表达。Clarithromycin减少人鼻腔上皮细胞和成纤维细胞中HIE或 IL-1 beta刺激的NF-kappa B的DNA结合活性。[5] 参考文献 [1] Kikuchi T, et al. J Antimicrob Chemother, 2002, 49(5), 745-755. [2] Ichiyama T, et al. Antimicrob Agents Chemother, 2001, 45(1), 44-47. [3] Khan AA, et al. Int J Antimicrob Agents, 1999, 11(2), 121-132. [4] Abe S, et al. Am J Respir Cell Mol Biol, 2000, 22(1), 51-60. [5] Miyanohara T, et al. Laryngoscope, 2000, 110(1), 126-131. 安全信息
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| R10967 | Alfa Aesar | Clarithromycin Standard solution | 100ppm | 419元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||
安全信息 危险等级 | |||||||||||||||||||||||||||||||||||||||||||||||
| SBR00011 | Sigma-Aldrich | Clarithromycin, Ready Made Solution | 50 mg/mL in DMSO | 2310.36元/2 ML; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions. 应用 Clarithromycin may be used for-
生化/生理作用 Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation. 包装 2ML 其他说明 Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids 基本信息
产品性质
安全信息
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