CAS 80751-85-5; sk&f 83959

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货号

品牌

产品名称

规格

包装、参考价格

详情

S2816

Sigma-Aldrich

SKF-83959 hydrobromide

≥98% (HPLC), solid

2660.07元/5 MG;

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产品说明

应用

SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice.

包装

5, 25 mg in glass bottle

生化/生理作用

SKF-83959 is an atypical agonist of D₁ dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D₁ receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D₁ receptors coupled to adenylyl cyclase.
D₁ dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.

基本信息

经验(实验)分子式	C₁₈H₂₀NClO₂ · HBr
分子量	398.72
MDL编号	MFCD03792727
PubChem化学物质编号	24278699
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	white
溶解性	DMSO: >20 mg/mL H₂O: insoluble
SMILES string	Br[H].CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c3cccc(C)c3
InChI	1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H
InChI key	FHYWNBUFNGHNCP-UHFFFAOYSA-N
Gene Information	human ... DRD1(1812)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)