| CAS: | 80489-90-3 | |
| 分子式: | C21H24O4 | |
| 分子量: | 340.4 | |
| 英文名称: |
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| 用途: | Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. fruticosa and G. foetida that exhibits antidiabetic effects. |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||
| A912707 | MACKLIN | Amorfrutin A | 98% | 4123元/500μg; | 展开 | ||||||||||||||||||||||
储存：-20°C，密闭，干燥 状态：白色固体 | |||||||||||||||||||||||||||
| SMB01019 | Sigma-Aldrich | Amorfrutin A | ≥90% (LC/MS-ELSD) | 4332元/1 MG; | 展开 | ||||||||||||||||||||||
产品说明 一般描述 Amorfrutin A is an isoprenoid-substituted benzoic acid natural product. 生化/生理作用 Amorfrutin A exhibits antidiabetic effects. It binds to PPARγ with a Ki of 0.236 μM and activates a PPARγ gene reporter assay with an EC50 value of 0.458 μM. In high-fat diet-induced obese (DIO) mice, Amorfrutin A (100 mg/kg/day) enhanced glucose tolerance and insulin sensitivity, while decreasing plasma triglycerides, free fatty acids, insulin, and glucose concentrations. Amorfrutin A inhibits TNF-α-induced expression of a number of inflammatory genes such as COX-2, IL-1β, MCP-1, MIP-2, MIP-3α, MMP-9, and IL-8 through inhibition of both NF-κB and PPARγ activity with efficacy at 5-20 μM. 基本信息
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